In vivo studies with a Candida tropicalis isolate exhibiting paradoxical growth in vitro in the presence of high concentration of caspofungin

Sedigh Bayegan, Laszlo Majoros, G. Kardos, Adam Kemény-Beke, Cecilia Miszti, Renato Kovacs, R. Gesztelyi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We investigated the activity of caspofungin against a Candida tropicalis clinical isolate showing paradoxical growth in vitro. BALB/c mice immunosuppressed by cyclophosphamide were infected intraperitoneally using 107 CFU/mouse. Caspofungin was administered intraperitoneally once daily for 5 days or as a single dose using the following doses: 0. 12, 0. 25, 1, 2, 3, 5, and 15 mg/kg. The single dose of caspofungin was effective only at 5 and 15 mg/kg concentrations (100% survival). Five-day caspofungin treatment led to 100% survival at doses of 1 mg/kg or higher. Caspofungin treatment significantly decreased the number of viable yeasts in the peritoneal lavage samples as well as in the infected abscesses at doses 1, 3, 5, and 15 mg/kg caspofungin as compared to the untreated control (P

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalJournal of Microbiology
Volume48
Issue number2
DOIs
Publication statusPublished - Apr 2010

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caspofungin
Candida tropicalis
Growth
Peritoneal Lavage
Cyclophosphamide
Abscess
In Vitro Techniques
Yeasts

Keywords

  • C. tropicalis
  • Caspofungin
  • Murine
  • Paradoxical growth

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Cite this

In vivo studies with a Candida tropicalis isolate exhibiting paradoxical growth in vitro in the presence of high concentration of caspofungin. / Bayegan, Sedigh; Majoros, Laszlo; Kardos, G.; Kemény-Beke, Adam; Miszti, Cecilia; Kovacs, Renato; Gesztelyi, R.

In: Journal of Microbiology, Vol. 48, No. 2, 04.2010, p. 170-173.

Research output: Contribution to journalArticle

Bayegan, Sedigh ; Majoros, Laszlo ; Kardos, G. ; Kemény-Beke, Adam ; Miszti, Cecilia ; Kovacs, Renato ; Gesztelyi, R. / In vivo studies with a Candida tropicalis isolate exhibiting paradoxical growth in vitro in the presence of high concentration of caspofungin. In: Journal of Microbiology. 2010 ; Vol. 48, No. 2. pp. 170-173.
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