In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent

Pál Surányi, Pál Kiss, Balazs Ruzsics, Brigitta C. Brott, Tamás Simor, Ada Elgavish, Robert A. Baker, Nada H. Saab-Ismail, Gabriel A. Elgavish

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The phenomenological tissue kinetics of Gd(ABE-DTTA) was investigated in myocardial infarction (MI). Reperfused infarction was generated by balloon catheter in closed-chest canines (N = 11). Forty-eight hours thereafter, inversion-recovery (IR)-prepared fast gradient-echo control images were acquired with varying inversion times (TIs). Precontrast R1 maps were calculated from the TI dependence of signal intensity (SI) using non-linear curve fitting. Then 0.05 mmol/kg Gd(ABE-DTTA) was administered I.V. In 11 dogs postcontrast R1 maps were generated at 24 hr and 48 hr postcontrast. In five dogs measurements were also repeated at 108 hr and 12 days. In one dog early measurement was carried out at 4 hr. ΔR1 values for blood and viable and infarcted myocardium were calculated at each time point by subtracting the precontrast R1 from the postcontrast R1. Gd(ABE-DTTA) showed significant, progressive accumulation into infarcts during the first 2 days (kin = 0.39 hr-1) and a delayed clearance (kout = 0.005 hr-1). Among the time points sampled, the maximum infarct ΔR1 was detected at 48 hr (1.72 s -1). Contrast agent (CA) in infarcted tissue was detectable for 12 days. Clearance from blood and viable myocardium occurred in parallel and was completed by 108 hr. Gd(ABE-DTTA) displays slow, tissue-persistent kinetics and partly intravascular, partly extravascular characteristics. It demonstrates high affinity for infarcted myocardium and induces highlighting of infarcts between 4 hr and 12 days following administration.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalMagnetic Resonance in Medicine
Volume58
Issue number1
DOIs
Publication statusPublished - Jul 1 2007

Keywords

  • Contrast agent kinetics
  • Magnetic resonance imaging
  • Myocardial infarction
  • R1-mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Surányi, P., Kiss, P., Ruzsics, B., Brott, B. C., Simor, T., Elgavish, A., Baker, R. A., Saab-Ismail, N. H., & Elgavish, G. A. (2007). In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Magnetic Resonance in Medicine, 58(1), 55-64. https://doi.org/10.1002/mrm.21249