In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd(BME-DTTA)

T. Símor, W. J. Chu, L. Johnson, A. Safranko, M. Doyle, G. M. Pohost, G. A. Elgavish

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background Contrast agent-enhanced magnetic resonance imaging (MRI) has the potential to visualize myocardial ischemia. To date, however, no agent has been found that has a sustained effect that allows MRI detection for the entire duration of ischemia and reperfusion and thus is useful in conjunction with stress test MRI. In this article, we introduce the gadolinium complex of N3,N6-bis(2'-myristoyloxyethyl)-1,8-dioxo-triethylene-tetraamine-N,N,N',N'- tetraacetic acid [Gd(BME-DTTA)], an agent potentially useful for such a purpose. Methods and Results Four protocols were carried out. ECG-triggered, partially T1-weighted, spin-echo MRI was used in protocols A through C. In protocol A, in nonischemic ferrets, 50 μmol/kg Gd(BME-DTTA) induced a 70±5% intensity enhancement lasting 3 hours. In protocol B, the left anterior descending coronary artery was occluded, and a 99mTc-sestamibi-induced autoradiographic contrast verified (r=.87, P

Original languageEnglish
Pages (from-to)3549-3559
Number of pages11
JournalCirculation
Volume92
Issue number12
Publication statusPublished - 1995

Fingerprint

Ferrets
Myocardial Reperfusion
Contrast Media
Myocardial Ischemia
Magnetic Resonance Imaging
Technetium Tc 99m Sestamibi
Gadolinium
Exercise Test
Reperfusion
Coronary Vessels
Electrocardiography
Ischemia
Acids
N(3),N(6)-bis(2'-myristoyloxyethyl)-1,8-dioxotriethylenetetramine-N,N,N',N'-tetraacetic acid

Keywords

  • Tc-sestamibi
  • contrast media
  • gadolinium
  • ischemia
  • magnetic resonance imaging
  • perfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Símor, T., Chu, W. J., Johnson, L., Safranko, A., Doyle, M., Pohost, G. M., & Elgavish, G. A. (1995). In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd(BME-DTTA). Circulation, 92(12), 3549-3559.

In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd(BME-DTTA). / Símor, T.; Chu, W. J.; Johnson, L.; Safranko, A.; Doyle, M.; Pohost, G. M.; Elgavish, G. A.

In: Circulation, Vol. 92, No. 12, 1995, p. 3549-3559.

Research output: Contribution to journalArticle

Símor, T, Chu, WJ, Johnson, L, Safranko, A, Doyle, M, Pohost, GM & Elgavish, GA 1995, 'In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd(BME-DTTA)', Circulation, vol. 92, no. 12, pp. 3549-3559.
Símor, T. ; Chu, W. J. ; Johnson, L. ; Safranko, A. ; Doyle, M. ; Pohost, G. M. ; Elgavish, G. A. / In vivo MRI visualization of acute myocardial ischemia and reperfusion in ferrets by the persistent action of the contrast agent Gd(BME-DTTA). In: Circulation. 1995 ; Vol. 92, No. 12. pp. 3549-3559.
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