In vivo measurements with a potassium ion-selective microelectrode based on a new bis(crown ether)

J. Tarcali, G. Nagy, K. Tóth, E. Pungor, G. Juhász, T. Kukorelli

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Potassium ion-selective microelectrodes with a tip diameter of 10 μm are described. The ionophore used is 2,2′-bis[3,4-(15-crown-5)-2-nitrophenylcarbamoxymethyl] tetradecane in a conventional mixture with sodium tetraphenylborate, an ether and PVC. The electrode provides Nernstian response over the range 10-5-10-1 M potassium activity. Its selectivity is shown to be similar to that of a valinomycin-based microelectrode. After the electrode has aged for 24 h, the 95% response time at the 10-3 M potassium ion level is 2.0 ± 0.5 s. The applicability of the bis(crown ether) electrode for measurements in vivo is proved by monitoring the changes in potassium activity in different areas of the brain of anaesthetized rats after administration of veratrine.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalAnalytica Chimica Acta
Volume178
Issue numberC
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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