In vivo labeling of serotonin-containing neurons by 5,7-dihydroxytryptamine in Aplysia

Behrus Jahan-Parwar, Katalin S.-Rozsa, J. Salánki, Martyn L. Evans, David O. Carpenter

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Intrahemocoelial administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia californica induces a transient (<4 h) behavioral alteration. About 5 weeks after 5,7-DHT treatment, 5-hydroxytryptamine (5-HT)-containing neurons develop dark brown pigmentation. These labeled 5-HT neurons have normal physiological and pharmacological properties when investigated electrophysiologically. This contrasts with the long-term neurotoxic effect of 5,7-DHT on vertebrate neurons. This technique will greatly facilitate visual identification of 5-HT-containing neurons and study of their physiology and actions.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBrain Research
Volume426
Issue number1
DOIs
Publication statusPublished - Nov 17 1987

Fingerprint

5,7-Dihydroxytryptamine
Aplysia
Serotonin
Neurons
Pigmentation
Vertebrates
Pharmacology

Keywords

  • 5,7-Dihydroxytryptamine
  • 5-Hydroxytryptamine
  • 5-Hydroxytryptamine neuron
  • Aplysia
  • In vivo labeling

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

In vivo labeling of serotonin-containing neurons by 5,7-dihydroxytryptamine in Aplysia. / Jahan-Parwar, Behrus; S.-Rozsa, Katalin; Salánki, J.; Evans, Martyn L.; Carpenter, David O.

In: Brain Research, Vol. 426, No. 1, 17.11.1987, p. 173-178.

Research output: Contribution to journalArticle

Jahan-Parwar, Behrus ; S.-Rozsa, Katalin ; Salánki, J. ; Evans, Martyn L. ; Carpenter, David O. / In vivo labeling of serotonin-containing neurons by 5,7-dihydroxytryptamine in Aplysia. In: Brain Research. 1987 ; Vol. 426, No. 1. pp. 173-178.
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