In vivo labeling of serotonin-containing neurons by 5,7-dihydroxytryptamine in Aplysia

Behrus Jahan-Parwar, Katalin S.-Rozsa, Janos Salanki, Martyn L. Evans, David O. Carpenter

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Intrahemocoelial administration of 5,7-dihydroxytryptamine (5,7-DHT) to Aplysia californica induces a transient (< 4 h) behavioral alteration. About 5 weeks after 5,7-DHT treatment, 5-hydroxytryptamine (5-HT)-containing neurons develop dark brown pigmentation. These labeled 5-HT neurons have normal physiological and pharmacological properties when investigated electrophysiologically. This contrasts with the long-term neurotoxic effect of 5,7-DHT on vertebrate neurons. This technique will greatly facilitate visual identification of 5-HT-containing neurons and study of their physiology and actions.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBrain research
Volume426
Issue number1
DOIs
Publication statusPublished - Nov 17 1987

Keywords

  • 5,7-Dihydroxytryptamine
  • 5-Hydroxytryptamine
  • 5-Hydroxytryptamine neuron
  • Aplysia
  • In vivo labeling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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