In vivo iontophoretic BDA injection through a buried microfluidic channel of a neural multielectrode

Z. Fekete, E. Pálfi, G. Márton, M. Handbauer, Zs Bérces, I. Ulbert, A. Pongrácz, L. Négyessy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This paper presents in vivo local iontophoretic release of a neuronal tracer, biotinylated dextran amine (BDA) in the rat brain using monolithically integrated microfluidic channel buried in a neural multielectrode. The tracer injection is controlled by iontophoresis using Pt electrodes in the vicinity of the outlet of the microfluidic channel. The successful injection is evaluated through histological maps of the labelled nerve cells in 3D. Together with previous electrophysiological studies we conclude that the presented device is capable of simultaneous in vivo multichannel neural recording and controlled tracer injection for mapping neuronal pathways of the brain.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
JournalProcedia Engineering
Volume120
DOIs
Publication statusPublished - 2015

Fingerprint

Dextran
Microfluidics
Amines
Brain
Neurons
Rats
Electrodes
Iontophoresis

Keywords

  • Cerebral cortex, rat
  • Electrophoresis
  • Neuronal tract tracing
  • Silicon microfabrication

ASJC Scopus subject areas

  • Engineering(all)

Cite this

In vivo iontophoretic BDA injection through a buried microfluidic channel of a neural multielectrode. / Fekete, Z.; Pálfi, E.; Márton, G.; Handbauer, M.; Bérces, Zs; Ulbert, I.; Pongrácz, A.; Négyessy, L.

In: Procedia Engineering, Vol. 120, 2015, p. 464-467.

Research output: Contribution to journalArticle

Fekete, Z. ; Pálfi, E. ; Márton, G. ; Handbauer, M. ; Bérces, Zs ; Ulbert, I. ; Pongrácz, A. ; Négyessy, L. / In vivo iontophoretic BDA injection through a buried microfluidic channel of a neural multielectrode. In: Procedia Engineering. 2015 ; Vol. 120. pp. 464-467.
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