Az A2A-adenozin-receptor-eloszlás in vivo tanulmányozása [11C]-CSC-radioliganddal.

Translated title of the contribution: In vivo investigation of the A2A adenosine receptor distribution using the [11C]-CSC radioligand

István Boros, Z. Lengyel, L. Balkay, Géza Horváth, A. József Szentmiklósi, I. Fekete, T. Márián

Research output: Contribution to journalArticle

Abstract

A 11C labeled selective adenosine A2A antagonist, (E)-8-(3-chlorostyryl)-1,3-dimethyl-7-[11C]-methylxanthine [(11C)-CSC] was prepared reacting (E)-8-(3-chlorostyryl)-1,3,-dimethylxanthine and [11C]-methyl iodide. A primary evaluation of [11C]-CSC as a potential tracer for mapping adenosine A2A receptors by positron emission tomography (PET) was also presented. Autoradiographic studies were carried out on Swiss mice. A high level accumulation of radioactivity was observed in the striatum and medulla oblongata in accordance with previous findings on the specific spatial distribution of A2A adenosine receptors. Dynamic PET studies on rabbits showed a fast brain uptake of CSC, reaching a maximum in less than 2 minutes. Competition experiments with the unlabeled ligand proved [11C]-CSC to bind specifically to the appropriate receptor.

Original languageHungarian
Pages (from-to)1317-1319
Number of pages3
JournalOrvosi Hetilap
Volume143
Issue number21 Suppl 3
Publication statusPublished - May 26 2002

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Adenosine A2A Receptors
Positron-Emission Tomography
Medulla Oblongata
Theophylline
Adenosine
Radioactivity
Rabbits
Ligands
Brain
methyl iodide
7-methylxanthine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az A2A-adenozin-receptor-eloszlás in vivo tanulmányozása [11C]-CSC-radioliganddal. / Boros, István; Lengyel, Z.; Balkay, L.; Horváth, Géza; Szentmiklósi, A. József; Fekete, I.; Márián, T.

In: Orvosi Hetilap, Vol. 143, No. 21 Suppl 3, 26.05.2002, p. 1317-1319.

Research output: Contribution to journalArticle

Boros, István ; Lengyel, Z. ; Balkay, L. ; Horváth, Géza ; Szentmiklósi, A. József ; Fekete, I. ; Márián, T. / Az A2A-adenozin-receptor-eloszlás in vivo tanulmányozása [11C]-CSC-radioliganddal. In: Orvosi Hetilap. 2002 ; Vol. 143, No. 21 Suppl 3. pp. 1317-1319.
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