In vivo incorporation of 3h-2,3-dl-valine in cholate-induced acute pancreatitis in rats

M. Papp, D. Szabo, C. Dzsinich, R. Machovich, G. B. Makara, G. Rappay

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pancreatitis was induced in rats with sodium deoxycholate or sodium taurocholate and they received intravenously 5 µCi/g or 0.55 µCi/g body weight of 2,3–3H-DL-valine, respectively, and the pancreas was removed. The number of grains counted per 1,000 µm2 was 298, 196 and 112 over the acini in the intact, the saline-treated, and the deoxycholate-treated glands, respectively. The differences are statistically insignificant. The grains were found to have decreased in number over the zymogen granules of the deoxycholate treated acinar parenchyma. Incorporation of the labeled valine into the pancreatic proteins was lowest in the taurocholate-treated, significantly higher in the saline-treated, and highest in the untreated animals. The lower uptake of amino acids by the inflamed pancreas resulted from lower protein synthesis, histological damage, and impaired local circulation.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalDigestion
Volume6
Issue number2
DOIs
Publication statusPublished - Jan 1 1972

Keywords

  • Bile acids and salts
  • Labelled
  • Pancreas
  • Pancreatitis
  • Proteins
  • Radioautography
  • Radioisotopes
  • Rats
  • Tritium
  • Valine

ASJC Scopus subject areas

  • Gastroenterology

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