Pancreatitis was induced in rats with sodium deoxycholate or sodium taurocholate and they received intravenously 5 µCi/g or 0.55 µCi/g body weight of 2,3–3H-DL-valine, respectively, and the pancreas was removed. The number of grains counted per 1,000 µm2 was 298, 196 and 112 over the acini in the intact, the saline-treated, and the deoxycholate-treated glands, respectively. The differences are statistically insignificant. The grains were found to have decreased in number over the zymogen granules of the deoxycholate treated acinar parenchyma. Incorporation of the labeled valine into the pancreatic proteins was lowest in the taurocholate-treated, significantly higher in the saline-treated, and highest in the untreated animals. The lower uptake of amino acids by the inflamed pancreas resulted from lower protein synthesis, histological damage, and impaired local circulation.
- Bile acids and salts
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