In vivo evaluation of retinal neurodegeneration in patients with multiple sclerosis

Erika Tátrai, Magdolna Simó, Anna Iljicsov, J. Németh, Delia Cabrera DeBuc, G. M. Somfai

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: To evaluate macular morphology in the eyes of patients with multiple sclerosis (MS) with or without optic neuritis (ON) in previous history. Methods: Optical coherence tomography (OCT) examination was performed in thirty-nine patients with MS and in thirty-three healthy subjects. The raw macular OCT data were processed using OCTRIMA software. The circumpapillary retinal nerve fiber layer (RNFL) thickness and the weighted mean thickness of the total retina and 6 intraretinal layers were obtained for each eye. The eyes of MS patients were divided into a group of 39 ON-affected eyes, and into a group of 34 eyes with no history of ON for the statistical analyses. Receiver operating characteristic (ROC) curves were constructed to determine which parameter can discriminate best between the non-affected group and controls. Results: The circumpapillary RNFL thickness was significantly decreased in the non-affected eyes compared to controls group only in the temporal quadrant (p = 0.001) while it was decreased in the affected eyes of the MS patients in all quadrants compared to the non-affected eyes (p

Original languageEnglish
Article numbere30922
JournalPLoS One
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 26 2012

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sclerosis
Multiple Sclerosis
Optics
eyes
Optical tomography
Optic Neuritis
optics
Fibers
tomography
nerve fibers
Optical Coherence Tomography
Nerve Fibers
Control Groups
retina
ROC Curve
Retina
Healthy Volunteers
Software

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

In vivo evaluation of retinal neurodegeneration in patients with multiple sclerosis. / Tátrai, Erika; Simó, Magdolna; Iljicsov, Anna; Németh, J.; DeBuc, Delia Cabrera; Somfai, G. M.

In: PLoS One, Vol. 7, No. 1, e30922, 26.01.2012.

Research output: Contribution to journalArticle

Tátrai, Erika ; Simó, Magdolna ; Iljicsov, Anna ; Németh, J. ; DeBuc, Delia Cabrera ; Somfai, G. M. / In vivo evaluation of retinal neurodegeneration in patients with multiple sclerosis. In: PLoS One. 2012 ; Vol. 7, No. 1.
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AU - Somfai, G. M.

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