In vivo effects of paraquat on some oxidative enzymes of mice

B. Matkovics, L. Szabó, Sz I. Varga, R. Novák, Katalin Barabás, G. Berencsi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1. By means of a comparison with untreated controls, a study was made of the effects of LD50 and LD100 of paraquat in vivo on the peroxide metabolism enzymes (superoxide dismutase, peroxidase and catalase), on the tissue lipid peroxidation, and on the microsomal cytochrome P-450 concentrations of the main organs. 2. The results reveal that the enzymes and the tissue properties compared are influenced by the herbicide in different manners, depending on its concentration. 3. The effect is connected first of all with the redox properties of paraquat, which in mice acts either as an electron donor or as an electron acceptor, depending on its concentration.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalGeneral Pharmacology
Volume11
Issue number3
DOIs
Publication statusPublished - 1980

Fingerprint

Paraquat
Electrons
Lethal Dose 50
Peroxides
Herbicides
Enzymes
Catalase
Cytochrome P-450 Enzyme System
Lipid Peroxidation
Peroxidase
Superoxide Dismutase
Oxidation-Reduction

ASJC Scopus subject areas

  • Pharmacology

Cite this

Matkovics, B., Szabó, L., Varga, S. I., Novák, R., Barabás, K., & Berencsi, G. (1980). In vivo effects of paraquat on some oxidative enzymes of mice. General Pharmacology, 11(3), 267-270. https://doi.org/10.1016/0306-3623(80)90039-7

In vivo effects of paraquat on some oxidative enzymes of mice. / Matkovics, B.; Szabó, L.; Varga, Sz I.; Novák, R.; Barabás, Katalin; Berencsi, G.

In: General Pharmacology, Vol. 11, No. 3, 1980, p. 267-270.

Research output: Contribution to journalArticle

Matkovics, B, Szabó, L, Varga, SI, Novák, R, Barabás, K & Berencsi, G 1980, 'In vivo effects of paraquat on some oxidative enzymes of mice', General Pharmacology, vol. 11, no. 3, pp. 267-270. https://doi.org/10.1016/0306-3623(80)90039-7
Matkovics, B. ; Szabó, L. ; Varga, Sz I. ; Novák, R. ; Barabás, Katalin ; Berencsi, G. / In vivo effects of paraquat on some oxidative enzymes of mice. In: General Pharmacology. 1980 ; Vol. 11, No. 3. pp. 267-270.
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