Fluorokinolonok in vivo étel-interakciós vizsgálatai

Translated title of the contribution: In vivo effect of food on absorption of fluoroquinolones

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Although food-drug interactions have been studied extensively in recent years, in the light of the complex nature of these interactions general guideline for clinical practice can not be given. Drug interactions with food (containing multivalent metal ions or protein) can have an influence on drug absorption with widely variety of mechanism, resulting in changes in both the rate and extent of bioavailability. Food-drug interaction can be important in the clinical practice. Studies of the interaction between food/juice and fluoroquinolones have produced conflicting results. A number of studies give evidence that fluoroquinolones forming slightly soluble complex with metal ions of food show reduced bioavailability. In the same time, concurrent ingestion of food/juice with fluoroquinolones has been shown not to interfere with their absorption to a clinically significant degree.

Original languageHungarian
Pages (from-to)81-87
Number of pages7
JournalActa pharmaceutica Hungarica
Volume79
Issue number2
Publication statusPublished - Jul 27 2009

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ASJC Scopus subject areas

  • Pharmaceutical Science

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