In vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis

László Marsovszky, Miklós D. Resch, J. Németh, Gergely Toldi, Erzsébet Medgyesi, László Kovács, Attila Balog

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Corneal Langerhans cells (LCs) offer the opportunity to gain insight into the activity of the innate immunity. We examined the density and the distribution of LCs and compared the results with dry-eye parameters in rheumatoid arthritis (RA). Fifty-two RA patients with various degrees of disease activity and 24 healthy subjects were enrolled. Peripheral and central LC number and morphology were assessed with in vivo laser confocal microscopy. In addition, ocular surface disease index (OSDI), lid parallel conjunctival folds, Schirmer test, and tear break-up time (TBUT) were evaluated. The prevalence of central and peripheral LC, and the central LC morphology values (LCM) were higher than normal in RA. Within the RA group, LC prevalence and morphology were not affected by disease activity. However, patients on anti-TNF or glucocorticosteroid (GCS) therapy exhibited normal LCM, and normal central and peripheral LC density. OSDI was higher and TBUT was lower than normal in RA. The alteration of LC in RA suggests an active inflammatory process in the cornea, which may reflect an increased activation state of the innate immune system - even in inactive stages of RA and without ocular symptoms. The results also indicate ocular effects of GCS therapy in RA.

Original languageEnglish
Pages (from-to)348-354
Number of pages7
JournalInnate Immunity
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Langerhans Cells
Rheumatoid Arthritis
Cell Count
Eye Diseases
Tears
Confocal Microscopy
Innate Immunity
Cornea
Immune System
Healthy Volunteers
Reference Values
Therapeutics

Keywords

  • Anti-TNF therapy
  • corneal Langerhans cell
  • in vivo confocal microscopy
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Immunology
  • Microbiology
  • Infectious Diseases

Cite this

In vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis. / Marsovszky, László; Resch, Miklós D.; Németh, J.; Toldi, Gergely; Medgyesi, Erzsébet; Kovács, László; Balog, Attila.

In: Innate Immunity, Vol. 19, No. 4, 08.2013, p. 348-354.

Research output: Contribution to journalArticle

Marsovszky, László ; Resch, Miklós D. ; Németh, J. ; Toldi, Gergely ; Medgyesi, Erzsébet ; Kovács, László ; Balog, Attila. / In vivo confocal microscopic evaluation of corneal Langerhans cell density, and distribution and evaluation of dry eye in rheumatoid arthritis. In: Innate Immunity. 2013 ; Vol. 19, No. 4. pp. 348-354.
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