In vivo characterization of Gd(BME-DTTA), a myocardial MRI contrast agent: Tissue distribution of its MRI intensity enhancement, and its effect on heart function

Wen Jang Chu, Tamas Simor, Gabriel A. Elgavish

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We have determined an LD50 of 0.56±0.05 mmol/kg for liposomal Gd(BME- DTTA) in mice and also shown that liposomal Gd(BME-DTTA) has no deleterious effects on heart rate, blood pressure, left ventricular force and AV conductance in ferret hearts in vivo at the magnetic resonance imaging (MRI)- effective dose of 0.05 mmol/kg body weight. In MRI images, a 1H signal intensity enhancement is observed in the following organs in decreasing order of the effect: heart≃spleen>kidney>liver. This enhancement is stable for over 3 h in all organs. The results of 1H MRI and electron micrographs indicate that the lipophilic fatty acyl groups in the ligand BME structure and the particle sizes of liposomal Gd(BME-DTTA) are two important factors for tissue specificity of liposomal Gd(BME-DTTA) in the intensity enhancement. In vitro relaxivity of a liposomal Gd(BME-DTTA) sample, stored at 4°C, remained stable for over 4 months of observation, but a significant decrease in relaxivity was observed in a sample stored at room temperature, most likely reflecting some deterioration in liposome chemistry.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalNMR in biomedicine
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 1 1997

Keywords

  • Cardiac MRI
  • Gd(BME-DTTA)
  • MRI contrast agents

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

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