In vivo cerebral blood flow autoregulation studies using rheoencephalography

M. Bodo, F. Pearce, A. Garcia, S. Van Albert, T. Settle, J. Szebeni, L. Baranyi, J. Hartings, R. Armonda

Research output: Contribution to journalConference article

2 Citations (Scopus)


Acute management of patients with traumatic brain/blast injury is a challenge. To minimize secondary injury and improve outcome, it is critical to detect neurological deterioration early, when it is potentially reversible. One potential monitoring method is cerebral electrical impedance (rheoencephalography-REG) because of its non-invasiveness and good time resolution. Reported here are the results of cerebral blood flow (CBF) manipulations comparing electroencephalogram (EEG) with REG (both intra-cerebral) and measuring with surface and skull REG electrodes. Our hypothesis was that REG would reflect spreading depression and CBF autoregulation. Animal experiments were performed using one rat (four trials with intracerebral electrodes), monkeys (n=8, with surface electrodes) and pigs (n 24 pigs with skull electrodes; 57 trials, 19 types of liposomes). Challenges included intracranial pressure (ICP) elevation, liposome infusion, and hemorrhage. Data were stored on a PC and evaluated off line. CBF autoregulation was evaluated both by visual inspection and by a Matlab script. These studies confirmed that REG reflects CBF autoregulation and that REG is useful for detecting spreading depression (SD), vasospasm and the lower limit of CBF autoregulation. These findings have clinical relevance for use in noninvasive neuro-monitoring in the neurosurgery intensive care and during transportation of patients with brain injury.

Original languageEnglish
Article number012088
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - Jan 1 2010
Event14th International Conference on Electrical Bioimpedance, Held in Conjunction with the 11th Conference on Biomedical Applications of EIT, ICEBI and EIT 2010 - Gainesville, FL, United States
Duration: Apr 4 2010Apr 8 2010


ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Bodo, M., Pearce, F., Garcia, A., Van Albert, S., Settle, T., Szebeni, J., Baranyi, L., Hartings, J., & Armonda, R. (2010). In vivo cerebral blood flow autoregulation studies using rheoencephalography. Journal of Physics: Conference Series, 224(1), [012088].