A nátrium-n-butirát hatásának in vivo és in vitro vizsgálata oxidatív stressz okozta bé lgyulladásokban

Translated title of the contribution: In vivo and in vitro examination of the effect of sodium-n-butyrate on oxidative stress-induced bowel inflammations

Pásztiné Gere Erzsébet, Palócz Orsolya, H. Fébel, Jakab Csaba, Gálfi Péter

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In oxidative stress-induced inflammatory processes damage to integrity of junctional assembly and increase in permeability of cell monolayer can happen dependently on ROS concentration and exposure time. The aim of the experimental work was to study the beneficial effect of therapeutically applied growth promoter, n-butyrate on bowel inflammation and oxidative tissue injury in vitro in non-transformed porcine intestinal epithelial cell line, IPEC-J2 cells grown on membrane inserts and in vivo fattening trial with growing pigs. Based on the results, the strengthening of epithelial barrier function and the maintenance of healthy microbiota in addition to promotion of regeneration of epithelium contribute greatly to therapeutic value of protective n-butyrate. The decrease in cell monolayer resistance induced by acute oxidative stress could be compensated by low dose butyrate treatment, which further supported that the mechanical barrier role of intestinal epithelium can be improved by butyrate supplementation in case of excessive oxidative stimuli. The findings confirm that the tipped balance of porcine intestinal milieu can be restored via enrichment of gut ecosystem with beneficial lactobacilli and consequently, their metabolites, L-lactic acids in small intestine when pigs are fed with sodium-n-butyrate. In addition, butyrate, via suppression of coliform bacteria proliferation, can act as an efficient agent in the prevention or treatment of bowel specific infectious diseases.

Original languageHungarian
Pages (from-to)726-732
Number of pages7
JournalMagyar Allatorvosok Lapja
Volume134
Issue number12
Publication statusPublished - Dec 2012

Fingerprint

Butyric Acid
Butyrates
butyrates
Oxidative Stress
oxidative stress
inflammation
sodium
Inflammation
Swine
swine
coliform bacteria
Microbiota
induced resistance
Lactobacillus
cells
Intestinal Mucosa
intestinal mucosa
lactic acid
infectious diseases
Small Intestine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

A nátrium-n-butirát hatásának in vivo és in vitro vizsgálata oxidatív stressz okozta bé lgyulladásokban. / Erzsébet, Pásztiné Gere; Orsolya, Palócz; Fébel, H.; Csaba, Jakab; Péter, Gálfi.

In: Magyar Allatorvosok Lapja, Vol. 134, No. 12, 12.2012, p. 726-732.

Research output: Contribution to journalArticle

Erzsébet, Pásztiné Gere ; Orsolya, Palócz ; Fébel, H. ; Csaba, Jakab ; Péter, Gálfi. / A nátrium-n-butirát hatásának in vivo és in vitro vizsgálata oxidatív stressz okozta bé lgyulladásokban. In: Magyar Allatorvosok Lapja. 2012 ; Vol. 134, No. 12. pp. 726-732.
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