In vitro testing of thiolated poly(Aspartic acid) from ophthalmic formulation aspects

Mária Budai-Szücs, Gabriella Horvát, Benjámin Gyarmati, Barnabás Á.Ron Szilágyi, András Szilágyi, Tímea Csihi, Szilvia Berkó, Piroska Szabó-Révész, Michela Mori, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Erzsébet Csányi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ocular drug delivery formulations must meet anatomical, biopharmaceutical, patient-driven and regulatory requirements. Mucoadhesive polymers can serve as a better alternative to currently available ophthalmic formulations by providing improved bioavailability. If all requirements are addressed, a polymeric formulation resembling the tear film of the eye might be the best solution. The optimum formulation must not have high osmotic activity, should provide appropriate surface tension, pH and refractive index, must be non-toxic and should be transparent and mucoadhesive. We would like to highlight the importance of in vitro polymer testing from a pharmaceutical aspect. We, therefore, carried out physical-chemical investigations to verify the suitability of certain systems for ophthalmic formulations. In this work, in situ gelling, mucoadhesive thiolated poly(aspartic acid)s were tested from ophthalmic formulation aspects. The results of preformulation measurements indicate that these polymers can be used as potential carriers in ophthalmic drug delivery.

Original languageEnglish
Pages (from-to)1241-1246
Number of pages6
JournalDrug development and industrial pharmacy
Volume42
Issue number8
DOIs
Publication statusPublished - Dec 7 2015

Keywords

  • Cytotoxicity
  • Mucoadhesion
  • Ocular drug delivery
  • Pharmaceutical preformulation
  • Rheology
  • Thiolated polymer

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Budai-Szücs, M., Horvát, G., Gyarmati, B., Szilágyi, B. Á. R., Szilágyi, A., Csihi, T., Berkó, S., Szabó-Révész, P., Mori, M., Sandri, G., Bonferoni, M. C., Caramella, C., & Csányi, E. (2015). In vitro testing of thiolated poly(Aspartic acid) from ophthalmic formulation aspects. Drug development and industrial pharmacy, 42(8), 1241-1246. https://doi.org/10.3109/03639045.2015.1118497