In vitro synergistic interactions of the effects of various statins and azoles against some clinically important fungi

Ildikó Nyilasi, Sándor Kocsubé, Krisztina Krizsán, László Galgóczy, Miklós Pesti, Tamás Papp, Csaba Vágvölgyi

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42 Citations (Scopus)

Abstract

The treatment of opportunistic fungal infections is often difficult as the number of available antifungal agents is limited. Nowadays, there is increasing interest in the investigation of the antifungal activity of nonantifungal drugs, and in the development of efficient antifungal combination therapy. In this study, the in vitro interactions of the effects of various statins (lovastatin, simvastatin, fluvastatin, atorvastatin (ATO), rosuvastatin (ROS) and pravastatin) and various azole antifungals [miconazole, ketoconazole, itraconazole and fluconazole (FLU)] against different opportunistic pathogenic fungi were investigated using a standard chequerboard broth microdilution method. When the investigated strains were sensitive to both compounds of the combination, additive interactions were frequently noticed. Synergistic interactions were observed in many cases when a strain was sensitive only to the azole compound (as in certain combinations with ATO or ROS) or the statin compound (as in certain combinations with FLU). In many combinations with an additive effect, the concentrations of drugs needed for total growth inhibition could be decreased by several dilution steps. Similar interactions were observed when the variability of the within-species sensitivities to some selected drug combinations was investigated.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalFEMS microbiology letters
Volume307
Issue number2
DOIs
Publication statusPublished - Jun 2010

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Keywords

  • Antifungal effect
  • Azole
  • Drug combination
  • Statin
  • Synergism

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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