In vitro synergistic interactions of the effects of various statins and azoles against some clinically important fungi

Ildikó Nyilasi, Sándor Kocsubé, Krisztina Krizsán, László Galgóczy, Miklós Pesti, Tamás Papp, Csaba Vágvölgyi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The treatment of opportunistic fungal infections is often difficult as the number of available antifungal agents is limited. Nowadays, there is increasing interest in the investigation of the antifungal activity of nonantifungal drugs, and in the development of efficient antifungal combination therapy. In this study, the in vitro interactions of the effects of various statins (lovastatin, simvastatin, fluvastatin, atorvastatin (ATO), rosuvastatin (ROS) and pravastatin) and various azole antifungals [miconazole, ketoconazole, itraconazole and fluconazole (FLU)] against different opportunistic pathogenic fungi were investigated using a standard chequerboard broth microdilution method. When the investigated strains were sensitive to both compounds of the combination, additive interactions were frequently noticed. Synergistic interactions were observed in many cases when a strain was sensitive only to the azole compound (as in certain combinations with ATO or ROS) or the statin compound (as in certain combinations with FLU). In many combinations with an additive effect, the concentrations of drugs needed for total growth inhibition could be decreased by several dilution steps. Similar interactions were observed when the variability of the within-species sensitivities to some selected drug combinations was investigated.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalFEMS Microbiology Letters
Volume307
Issue number2
DOIs
Publication statusPublished - 2010

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Azoles
fluvastatin
Fluconazole
Fungi
Miconazole
Pravastatin
Lovastatin
Ketoconazole
Itraconazole
Simvastatin
Mycoses
Antifungal Agents
Opportunistic Infections
Drug Combinations
Pharmaceutical Preparations
Growth
Rosuvastatin Calcium
Atorvastatin Calcium
In Vitro Techniques

Keywords

  • Antifungal effect
  • Azole
  • Drug combination
  • Statin
  • Synergism

ASJC Scopus subject areas

  • Microbiology
  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

In vitro synergistic interactions of the effects of various statins and azoles against some clinically important fungi. / Nyilasi, Ildikó; Kocsubé, Sándor; Krizsán, Krisztina; Galgóczy, László; Pesti, Miklós; Papp, Tamás; Vágvölgyi, Csaba.

In: FEMS Microbiology Letters, Vol. 307, No. 2, 2010, p. 175-184.

Research output: Contribution to journalArticle

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