In vitro susceptibility of clinically important zygomycetes to combinations of amphotericin B and suramin

L. Galgóczy, L. Ördögh, M. Virágh, T. Papp, Cs Vágvölgyi

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Abstract

The in vitro antifungal activity of suramin (25-300 μg/ml) and its combinations with amphotericin B (0.024-12.5 μg/ml) against 15 zygomycetes isolates representing nine clinically important genera (Absidia, Micromucor, Mortierella, Mycocladus, Mucor, Rhizomucor, Rhizopus, Saksenaea and Syncephalastrum) were tested. The investigated compounds acted antagonistically, synergistically and/or additively on the growth when a strain was sensitive to both compounds or resistant to suramin and sensitive to amphotericin B. At the same time, synergistic interactions were detected if strains were insensitive to both agents. In the case, when a fungus was sensitive to suramin but resistant to amphotericin B, inhibitory effect of only the suramin was measured.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalJournal de Mycologie Medicale
Volume19
Issue number4
DOIs
Publication statusPublished - Dec 1 2009

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Keywords

  • Amphotericin B
  • Drug combinations
  • MIC
  • Suramin
  • Zygomycetes

ASJC Scopus subject areas

  • Infectious Diseases

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