In vitro study of antibiotic effect on bacterial adherence to acrylic intraocular lenses

Valéria Gaál, F. Kilár, Barnabás Ács, Zsuzsanna Szijjártó, Béla Kocsis, Ildikó Kustos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Implantation of artificial intraocular lenses into the eye during ophthalmic surgical procedures ensures an unliving surface on which bacterial pathogens may attach and form biofilms. Despite antibiotic treatment bacteria growing in biofilms might cause inflammation and serious complications. In this study the adhesive ability of 7 Staphylococcus aureus and 11 coagulase-negative Staphylococcus (CNS) strains to the surface of acrylic intraocular lenses had been examined by the ultrasonic method. In untreated cases adhesion of the S. aureus and CNS strains did not differ significantly. We could not demonstrate significant differences between the adhesive ability of the standard strains and the clinical isolates. In this study a single - 60 min long - antibiotic (ciprofloxacin and tobramycin) treatment had been applied, that correlate well with the single or intermittant antibiotic prophylaxis of patients. Ciprofloxacin administration was able to reduce significantly the number of attached cells on the surface of acrylic lenses both in the case of S. aureus and CNS strains. Dependence of the effect from concentration could also be demonstrated. Tobramycin treatment was able to inhibit significantly the attachment of S. aureus cells. Despite the debate on antibiotic prophylaxis we presented in our experiments that a single antibiotic administration can decrease the attachment of bacterial cells to the surface of acrylic intraocular lenses, and might be effective in the prevention of postoperative endophthalmitis, that is a rare but serious complication of ophthalmic surgery.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Volume45
Issue number3-4
DOIs
Publication statusPublished - Nov 10 2005

Fingerprint

Intraocular lenses
antibiotics
Intraocular Lenses
Antibiotics
staphylococcus
Acrylics
Staphylococcus aureus
Coagulase
Staphylococcus
lenses
Anti-Bacterial Agents
prophylaxis
Tobramycin
Antibiotic Prophylaxis
Ciprofloxacin
Biofilms
biofilms
Adhesives
adhesives
attachment

Keywords

  • Acrylic intraocular lens
  • Adhesive ability
  • Antibiotic effect
  • Staphylococcus

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

In vitro study of antibiotic effect on bacterial adherence to acrylic intraocular lenses. / Gaál, Valéria; Kilár, F.; Ács, Barnabás; Szijjártó, Zsuzsanna; Kocsis, Béla; Kustos, Ildikó.

In: Colloids and Surfaces B: Biointerfaces, Vol. 45, No. 3-4, 10.11.2005, p. 125-130.

Research output: Contribution to journalArticle

Gaál, Valéria ; Kilár, F. ; Ács, Barnabás ; Szijjártó, Zsuzsanna ; Kocsis, Béla ; Kustos, Ildikó. / In vitro study of antibiotic effect on bacterial adherence to acrylic intraocular lenses. In: Colloids and Surfaces B: Biointerfaces. 2005 ; Vol. 45, No. 3-4. pp. 125-130.
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