In-vitro-untersuchung der mikrostruktur von handelsüblichen ophthalmologischen suspensionen mittels HRT-II Rostock Cornea Modul

Translated title of the contribution: In vitro microstructural analysis of commercial ophthalmic suspensions by HRT II Rostock Cornea Module

L. Imre, M. Resch, M. Megyesi, J. Németh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. To investigate the particles of commercially used ophthalmic suspensions with the HRT II Rostock Cornea Module and to compare them with particle parameters given in the literature. Methods. Software-aided analysis was carried out for the suspensions brinzolamide 1%, betaxolol HCl 0.25%, dexamethasone phosphate 0.1% and prednisolone acetate 0.5%, including measurements of length, area and circumference and calculation of ellipticity and shape factor (SF). Results. Particle characteristics (SF and ellipticity) of different suspensions demonstrated that the particles are not spherical. Significant aggregation affinity of prednisolone acetate particles was observed. Conclusion. Exact and reproducible in vitro microstructural examination of ophthalmic suspensions was possible due to the high resolution of the HRT II Rostock Cornea Module.

Original languageGerman
Pages (from-to)697-704
Number of pages8
JournalOphthalmologe
Volume104
Issue number8
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Cornea
Suspensions
dexamethasone 21-phosphate
Betaxolol
Software
In Vitro Techniques
prednisolone acetate

Keywords

  • Confocal Microscopy
  • HRT II+RCM
  • Ophthalmic suspension
  • Particle

ASJC Scopus subject areas

  • Ophthalmology

Cite this

In-vitro-untersuchung der mikrostruktur von handelsüblichen ophthalmologischen suspensionen mittels HRT-II Rostock Cornea Modul. / Imre, L.; Resch, M.; Megyesi, M.; Németh, J.

In: Ophthalmologe, Vol. 104, No. 8, 08.2007, p. 697-704.

Research output: Contribution to journalArticle

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AU - Németh, J.

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