In vitro interactions between primycin and different statins in their effects against some clinically important fungi

Ildikó Nyilasi, S. Kocsubé, M. Pesti, Gyöngyi Lukács, T. Papp, C. Vágvölgyi

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19 Citations (Scopus)

Abstract

The in vitro antifungal activities of primycin (PN) and various statins against some opportunistic pathogenic fungi were investigated. PN completely inhibited the growth of Candida albicans (MIC 64 μg ml-1) and Candida glabrata (MIC 32 μg ml-1), and was very effective against Paecilomyces variotii (MIC 2 μg ml-1), but had little effect on Aspergillus fumigatus, Aspergillus flavus or Rhizopus oryzae (MICs >64 μg ml-1). The fungi exhibited different degrees of sensitivity to the statins; fluvastatin (FLV) and simvastatin (SIM) exerted potent antifungal activities against a wide variety of clinically important fungal pathogens. Atorvastatin, rosuvastatin and lovastatin (LOV) had a slight effect against all fungal isolates tested, whereas pravastatin was completely ineffective. The in vitro interactions between PN and the different statins were investigated using a standard chequerboard titration method. When PN was combined with FLV, LOV or SIM, both synergistic and additive effects were observed. The extent of inhibition was higher when these compounds were applied together, and the concentrations of PN and the given statin needed to block fungal growth completely could be decreased by several dilution steps. Similar interactions were observed when the variability of the within-species sensitivities was investigated.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalJournal of Medical Microbiology
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
fluvastatin
Fungi
Lovastatin
Simvastatin
Paecilomyces
Candida glabrata
Pravastatin
Rhizopus
Aspergillus flavus
Aspergillus fumigatus
Growth
Candida albicans
primycin
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

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abstract = "The in vitro antifungal activities of primycin (PN) and various statins against some opportunistic pathogenic fungi were investigated. PN completely inhibited the growth of Candida albicans (MIC 64 μg ml-1) and Candida glabrata (MIC 32 μg ml-1), and was very effective against Paecilomyces variotii (MIC 2 μg ml-1), but had little effect on Aspergillus fumigatus, Aspergillus flavus or Rhizopus oryzae (MICs >64 μg ml-1). The fungi exhibited different degrees of sensitivity to the statins; fluvastatin (FLV) and simvastatin (SIM) exerted potent antifungal activities against a wide variety of clinically important fungal pathogens. Atorvastatin, rosuvastatin and lovastatin (LOV) had a slight effect against all fungal isolates tested, whereas pravastatin was completely ineffective. The in vitro interactions between PN and the different statins were investigated using a standard chequerboard titration method. When PN was combined with FLV, LOV or SIM, both synergistic and additive effects were observed. The extent of inhibition was higher when these compounds were applied together, and the concentrations of PN and the given statin needed to block fungal growth completely could be decreased by several dilution steps. Similar interactions were observed when the variability of the within-species sensitivities was investigated.",
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AU - Nyilasi, Ildikó

AU - Kocsubé, S.

AU - Pesti, M.

AU - Lukács, Gyöngyi

AU - Papp, T.

AU - Vágvölgyi, C.

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