In vitro degradation of β-amyloid[25-35] peptide

K. Jost, J. Varga, B. Penke, M. Zarándi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Some amyloid-derived peptides show their toxic effects only after a long "aging" period performed several days at pH 7.4 and 37°C for cluster formation. Our experiments show that long aging of β-amyloid[25-35] under physiological conditions results in peptide bond cleavage between Asn27 and Lys28. Relatively short incubation time (24 hours) and absence of Ca2+ ions prevent peptide cleavage and results in good aggregation of β-amyloids.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalProtein and Peptide Letters
Volume8
Issue number6
DOIs
Publication statusPublished - Dec 27 2001

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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