In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons

Tünde Hidvégi, Béla Schmidt, L. Varga, Mária Dervaderics, Ákos Lantos, Zsuzsanna Gönczi, József Barok, Miklós Otos, Michael Kirschfink, Peter Späth, G. Füst

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19 Citations (Scopus)

Abstract

Ragweed allergen (RWA)-induced complement activation in sera of 40 RW allergic patients and of 40 non-allergic controls was investigated. After treatment of the sera with RWA, levels of C3a, C5a, C3bBbP, ClrClsClinh, SC5b-9 and granulocyte-aggregating activity were determined. Concentration of RW-specific IgG was also measured. After RWA treatment dose-dependent complement activation was detected in sera of RW allergic and non-allergic persons. C3a generation was observed mostly in the sera of RW allergic individuals, while levels of C3bBbP and of RW-specific IgG were significantly higher in sera of allergics, and a strong correlation was found between these two parameters. In a prospective clinical study, a significant positive correlation was observed between the extent of RWA-induced alternative pathway (AP) activation and the severity of symptoms of allergic rhinoconjunctivitis that were developed in a 4-week period subsequent to blood sampling. These observations suggest that complement activation has a role in the development of the symptoms of RW allergy.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalImmunology Letters
Volume48
Issue number1
DOIs
Publication statusPublished - 1995

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Ambrosia
Complement Activation
Allergens
Serum
Immunoglobulin G
Granulocytes
Hypersensitivity
In Vitro Techniques
Prospective Studies
Therapeutics

Keywords

  • Asthma bronchiale
  • Complement activation
  • Ragweed allergy
  • Rhinoconjunctivitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons. / Hidvégi, Tünde; Schmidt, Béla; Varga, L.; Dervaderics, Mária; Lantos, Ákos; Gönczi, Zsuzsanna; Barok, József; Otos, Miklós; Kirschfink, Michael; Späth, Peter; Füst, G.

In: Immunology Letters, Vol. 48, No. 1, 1995, p. 65-71.

Research output: Contribution to journalArticle

Hidvégi, T, Schmidt, B, Varga, L, Dervaderics, M, Lantos, Á, Gönczi, Z, Barok, J, Otos, M, Kirschfink, M, Späth, P & Füst, G 1995, 'In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons', Immunology Letters, vol. 48, no. 1, pp. 65-71. https://doi.org/10.1016/0165-2478(95)02445-X
Hidvégi, Tünde ; Schmidt, Béla ; Varga, L. ; Dervaderics, Mária ; Lantos, Ákos ; Gönczi, Zsuzsanna ; Barok, József ; Otos, Miklós ; Kirschfink, Michael ; Späth, Peter ; Füst, G. / In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons. In: Immunology Letters. 1995 ; Vol. 48, No. 1. pp. 65-71.
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