In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers

J. Molnar, B. Tarodi, M. Galfi, B. Matkovics, N. Motohashi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Some of the phenothiazines and dibenz[b,f]azepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leukocytes. The superoxide dismutase inhibition by 7,8-dioxochlorpromazine and 6,9-dioxochlorpromazine have some relation to the growth inhibitory action on the growth of HEP-2 and prolactinoma cells in vitro. The antiproliferative effects of phenothiazines were synergized with resistance modifiers like verapamil, omeprazole and tubulozole-C, due to increased drug-influx or decreased drug-efflux and due to possible action on the cytoskeleton.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalAnticancer research
Volume12
Issue number1
Publication statusPublished - Jan 1 1992

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Keywords

  • Antiproliferative effects
  • Chemiluminescence of granulocytes
  • Chlorpromazine
  • HEp-2 cells
  • Imipramine derivatives
  • Prolactinoma
  • Superoxide dismutase
  • Synergism with resistance modifiers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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