In vitro antiproliferation in prostate cancer cell lines with cytostatics and combinations with resistance modifiers

Olivér Pintér, I. Mucsi, J. Molnár

Research output: Contribution to journalArticle

Abstract

The treatment of prostate cancer in an advanced state is still unsatisfactory. In the event of the ineffectiveness of total androgen blockade (TAB) therapy, cytostatic administration may be attempted. In this study, we modelled the drugs used in practice on human prostate cancer cell lines. Studies aimed at decreasing multidrug resistance were performed on PC-3 cells. With the use of various cytostatics, the cell proliferation-inhibiting effects were measured under in vitro conditions on human prostate cancer cell lines LNCaP-FGC and PC-3. Under the given experimental conditions, the examined cytostatics exhibited antiproliferative effects on each of the investigated cell lines. Our results indicate that it is not necessary to wait until the development of a hormone-resistant state. In the studies on the PC-3 cell line, we did not find a multidrug-resistant efflux activity responsible for the resistance of the tumour.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalIn Vivo
Volume19
Issue number1
Publication statusPublished - Jan 2005

Fingerprint

Cytostatic Agents
Prostatic Neoplasms
Cells
Cell Line
Cell proliferation
Multiple Drug Resistance
Androgens
Tumors
Cell Proliferation
Hormones
In Vitro Techniques
Pharmaceutical Preparations
Neoplasms
Therapeutics

Keywords

  • Multidrug resistance
  • Prostate cancer cell line
  • Resistance modifiers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

In vitro antiproliferation in prostate cancer cell lines with cytostatics and combinations with resistance modifiers. / Pintér, Olivér; Mucsi, I.; Molnár, J.

In: In Vivo, Vol. 19, No. 1, 01.2005, p. 253-260.

Research output: Contribution to journalArticle

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