In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine

B. Horváth, Zsolt Marton, R. Halmosi, Tamas Alexy, L. Szapáry, Judit Vekasi, Zsolt Biro, Tamas Habon, Gabor Kesmarky, K. Tóth

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Oxygen-free radicals play an important role in several physiologic and pathophysiologic processes. In pathologic circumstances, they can modify and damage biologic systems. Because oxygen-free radicals are involved in a wide range of diseases (cerebrovascular, cardiovascular, etc.), scavenging these radicals should be considered as an important therapeutic approach. In our in vitro study, we investigated the antioxidant capacity of three drugs: pentoxiphylline (Sigma Aldrich, St. Louis, MO, USA) piracetam (Sigma Aldrich), and vinpocetine (Richter Gedeon RT, Budapest, Hungary). Phenazine methosulphate was applied to generate free radicals, increasing red blood cell rigidity. Filtration technique and potassium leaking were used to detect the cellular damage and the scavenging effect of the examined drugs. According to our results, at human therapeutic serum concentration, only vinpocetine (Richter Gedeon RT) had significant (p <0.01) scavenging activity with a protective effect that increased further at higher concentrations. Pentoxiphylline (Sigma Aldrich) and piracetam (Sigma Aldrich) did not have significant antioxidant capacity at therapeutic concentrations, but increasing their concentrations (pentoxiphylline at 100-times, and piracetam at 10-times higher concentrations) led to a significant (p <0.01) scavenger effect. Our findings suggest that this pronounced antioxidant effect of vinpocetine and even the milder scavenging capacity of pentoxiphylline and piracetam may be of value in the treatment of patients with cerebrovascular disorders, but merits further investigations.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalClinical Neuropharmacology
Volume25
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

vinpocetine
Piracetam
Pentoxifylline
Antioxidants
Free Radicals
Cerebrovascular Disorders
Reactive Oxygen Species
Methylphenazonium Methosulfate
Hungary
Therapeutics
Pharmaceutical Preparations
Potassium
Cardiovascular Diseases
Erythrocytes
vinpocetine drug combination piracetam
In Vitro Techniques
Serum

Keywords

  • Antioxidants
  • Cerebrovascular drugs
  • Oxygen-free radicals
  • Red-blood-cell deformability

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. / Horváth, B.; Marton, Zsolt; Halmosi, R.; Alexy, Tamas; Szapáry, L.; Vekasi, Judit; Biro, Zsolt; Habon, Tamas; Kesmarky, Gabor; Tóth, K.

In: Clinical Neuropharmacology, Vol. 25, No. 1, 2002, p. 37-42.

Research output: Contribution to journalArticle

Horváth, B. ; Marton, Zsolt ; Halmosi, R. ; Alexy, Tamas ; Szapáry, L. ; Vekasi, Judit ; Biro, Zsolt ; Habon, Tamas ; Kesmarky, Gabor ; Tóth, K. / In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. In: Clinical Neuropharmacology. 2002 ; Vol. 25, No. 1. pp. 37-42.
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