In vitro antifungal activity of phenothiazines and their combination with amphotericin B against different Candida species

László Galgóczy, Andrea Bácsi, Mónika Homa, Máté Virágh, T. Papp, C. Vágvölgyi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Candidiosis is a mycosis that is currently increasingly affecting the population in consequence of its frequency and the severity of its complications, especially among immunocompromised hosts. In this work, the in vitro anticandidal activities of two phenothiazines (PTZs), chlorpromazine (CPZ) and trifluoperazine (TFP), and their combinations with amphotericin B (AMB) were tested against 12 different Candida strains representing 12 species (Candida albicans, Candida glabrata, Candida guillermondii, Candida inconspicua, Candida krusei, Candida lusitaniae, Candida lypolitica, Candida norvegica, Candida parapsilosis, Candida pulcherrima, Candida tropicalis and Candida zeylanoides). When used alone, both tested PTZs exerted antifungal effects against these strains. In their combinations, these PTZs and AMB mainly acted antagonistically at higher concentrations, but additively and synergistically at lower concentrations as concerns the clinically most important species (C. albicans and C. parapsilosis). For C. albicans, only synergistic interactions were revealed between CPZ and AMB. Synergistic, additive or no interactions were demonstrated between the investigated compounds for the most PTZ-susceptible (C. glabrata to TFP and C. krusei to CPZ) and insusceptible strains (C. glabrata to CPZ and C. lypolitica to TFP).

Original languageEnglish
JournalMycoses
Volume54
Issue number6
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Phenothiazines
Amphotericin B
Candida
Chlorpromazine
Candida glabrata
Trifluoperazine
Candida albicans
In Vitro Techniques
Candida tropicalis
Mycoses
Immunocompromised Host

Keywords

  • Amphotericin B
  • Candida spp.
  • Chlorpromazine
  • Drug interaction
  • Trifluoperazine

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

In vitro antifungal activity of phenothiazines and their combination with amphotericin B against different Candida species. / Galgóczy, László; Bácsi, Andrea; Homa, Mónika; Virágh, Máté; Papp, T.; Vágvölgyi, C.

In: Mycoses, Vol. 54, No. 6, 11.2011.

Research output: Contribution to journalArticle

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