In vitro antifungal activity of antipsychotic drugs and their combinations with conventional antifungals against Scedosporium and Pseudallescheria isolates

Mónika Homa, László Galgóczy, Eszter Tóth, Liliána Tóth, Tamás Papp, Muthusamy Chandrasekaran, Shine Kadaikunnan, Naiyf S. Alharbi, Csaba Vágvölgyi

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8 Citations (Scopus)

Abstract

In the present study, in vitro antifungal activities of five antipsychotic drugs (i.e., chlorpromazine hydrochloride, CPZ; trifluoperazine hydrochloride, TPZ; amantadine hydrochloride; R-(-)-deprenyl hydrochloride, and valproic acid sodium salt) and five conventional antifungal drugs (i.e., amphotericin B, AMB; caspofungin, CSP; itraconazole; terbinafine, TRB and voriconazole, VRC) were investigated in broth microdilution tests against four clinical and five environmental Scedosporium and Pseudallescheria isolates. When used alone, phenothiazines CPZ and TPZ exerted remarkable antifungal effects. Thus, their in vitro combinations with AMB, CSP, VRC, and TRB were also examined against the clinical isolates. In combination with antifungal agents, CPZ was able to act synergistically with AMB and TRB in cases of one and two isolates, respectively. In all other cases, indifferent interactions were revealed. Antagonism was not observed between the tested agents. These combinations may establish a more effective and less toxic therapy after further in vitro and in vivo studies for Scedosporium and Pseudallescheria infections.

Original languageEnglish
Pages (from-to)890-895
Number of pages6
JournalMedical mycology
Volume53
Issue number8
DOIs
Publication statusPublished - Jul 13 2015

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Keywords

  • Pseudallescheria spp.
  • Scedosporium spp.
  • antipsychotic drugs
  • drug interactions

ASJC Scopus subject areas

  • Infectious Diseases

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