In vitro and in vivo pharmacology of novel naltrindole-related compounds

A. Z. Ronai, K. Gyires, H. Schmidhammer, S. Hosztafi, A. Borsodi, M. Spetea, T. Friedmann, P. Riba, Z. Furst

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2 Citations (Scopus)


The pharmacological and receptor binding properties of some novel naltrindole (NTI) and naltrexone benzofurane (NTB) derivatives, modified at positions 3, 5, 14 and 17 were studied. Of the N-(17)-methyl NTI-derivatives, the 14-O-methyl derivative was a potent, highly selective δ opioid agonist whereas the 5-methyl derivative of the latter was a moderately potent μ agonist. Of the N-(17)-methyl NTB derivatives the 3,14-OH compound was a potent δ antagonist whereas the 3-O-methyl, 14-OH derivative was a moderately potent mixed agonist/antagonist at the same receptor. The N-methyl, 14-O-methyl NTI derivative ('morphindole') had in vivo a potent gastroprotective effect in rats in the ethanol-induced ulcer model.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalMedical Science Monitor
Issue number1
Publication statusPublished - Jan 1 1997



  • N-methyl naltrexone-benzofurane derivatives
  • N-methyl naltrindole-derivatives (morphindoles)
  • gastroprotective effect
  • isolated organs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ronai, A. Z., Gyires, K., Schmidhammer, H., Hosztafi, S., Borsodi, A., Spetea, M., Friedmann, T., Riba, P., & Furst, Z. (1997). In vitro and in vivo pharmacology of novel naltrindole-related compounds. Medical Science Monitor, 3(1), 1-5.