In vitro and in vivo evaluation of drug release from semisolid dosage forms

Éva Petró, Á Balogh, G. Blazsó, I. Erös, I. Csóka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study presents the in vitro and in vivo testing of anti-inflammatory drug containing creams, hydrogels and organogels for dermal use. In vitro penetration studies were performed with products by measuring the diffused drug amount through synthetic membranes soaked in isopropyl myristate (IPM). Our developed preparations were investigated under in vitro conditions together with two marketed medicinal products used as reference preparations. In vivo studies were carried out on anaesthetized male Wistar rats; the carrageenan-induced paw oedema decreasing effect of twelve different formulations and the reference products were measured in comparison with a control group. All - previously in vitro screened - selected products reduced paw oedema in rats. Significant differences were found among the developed products both in vitro and in vivo. Correlation between the in vitro penetration studies and in vivo results were found in the case of o/w creams, organogels and hydrogels.

Original languageEnglish
Pages (from-to)936-941
Number of pages6
JournalPharmazie
Volume66
Issue number12
DOIs
Publication statusPublished - 2011

Fingerprint

Dosage Forms
Hydrogels
Edema
Carrageenan
Pharmaceutical Preparations
Drug Liberation
In Vitro Techniques
Wistar Rats
Anti-Inflammatory Agents
Control Groups
Skin
Membranes

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

In vitro and in vivo evaluation of drug release from semisolid dosage forms. / Petró, Éva; Balogh, Á; Blazsó, G.; Erös, I.; Csóka, I.

In: Pharmazie, Vol. 66, No. 12, 2011, p. 936-941.

Research output: Contribution to journalArticle

Petró, É, Balogh, Á, Blazsó, G, Erös, I & Csóka, I 2011, 'In vitro and in vivo evaluation of drug release from semisolid dosage forms', Pharmazie, vol. 66, no. 12, pp. 936-941. https://doi.org/10.1691/ph.2011.1079
Petró, Éva ; Balogh, Á ; Blazsó, G. ; Erös, I. ; Csóka, I. / In vitro and in vivo evaluation of drug release from semisolid dosage forms. In: Pharmazie. 2011 ; Vol. 66, No. 12. pp. 936-941.
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