In vitro and in vivo biomechanics of the rat saphenous vein. Changes with two weeks of head-up tilting

G. Nádasy, M. Lorant, E. Monos

Research output: Contribution to journalArticle

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Abstract

The effects of short range and long range pressure changes on the geometry and biomechanics of a superficial leg vein were systematically studied. In vivo and in vitro pressure-diameter curves were taken on the rat saphenous vein of control animals and of animals kept in special head-up tilting cages for two weeks. Pressure-induced acute changes in diameter were not extensive. E.g. raising in vivo venous pressure from 7.9±1.1 to 30.3±1.5 mmHg increased outer diameter only by 5.1%, lowering it to 0.8±0.2 mmHg decreased the latter only by 8.8%. On the other hand, 12 μM norepinephrine and 40 nM endothelin-I reduced in vivo outer diameter at physiological pressures by 18.4 and 64.2%, respectively. Two weeks of elevated leg venous pressure by tilt position increased the diameter of the saphenous vein (e.g. inner radii at 10 mmHg, in vitro, 305±17 and 356±17 μm, p

Original languageEnglish
JournalFASEB Journal
Volume12
Issue number5
Publication statusPublished - Mar 20 1998

Fingerprint

saphenous vein
Biomechanics
Saphenous Vein
Biomechanical Phenomena
Rats
Head
Pressure
Venous Pressure
rats
Leg
Endothelins
legs
Animals
Veins
Norepinephrine
endothelins
norepinephrine
In Vitro Techniques
biomechanics
animals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

In vitro and in vivo biomechanics of the rat saphenous vein. Changes with two weeks of head-up tilting. / Nádasy, G.; Lorant, M.; Monos, E.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

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