In vitro and in vivo activities of ciprofloxacin and levofloxacin against an SHV-5 extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain

D. Szabó, András Máthé, József Lengyel, Piroska Anderlik, László Rókusz, F. Rozgonyi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Activities of ciprofloxacin and levofloxacin against an SHV-5 extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain were studied in vitro and in vivo in septic mice using a high inoculum. Susceptibility to ciprofloxacin and levofloxacin was independent of the inoculum size. In killing curve studies, after 24 hours the initial 7.69 log10 CFU/ml increased in the control to 9.34, while it was reduced to 4.83 by ciprofloxacin and to 4.25 by levofloxacin. Mice were infected with 107 CFU/g of K. pneumoniae intraperitoneally. Treatment started 2 hours later, when the mean blood bacterial counts were 7.33 log10 CFU/ml, and lasted for 26 hours from the time of infection. Blood bacterial count was reduced from 7.33 log10 CFU/ml to 4.08 log10 CFU/ml by ciprofloxacin (20mg/kg/6 hours), and to 3.60 log10 CFU/ml by levofloxacin (50 mg/kg/6 hours) 8 hours after the infection, which differed significantly from the infected untreated group. Ciprofloxacin and levofloxacin prolonged significantly the survival of mice compared with the infected untreated group (p

Original languageEnglish
Pages (from-to)437-442
Number of pages6
JournalCurrent Medicinal Chemistry
Volume9
Issue number4
Publication statusPublished - 2002

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Levofloxacin
Klebsiella pneumoniae
Ciprofloxacin
Bacterial Load
Blood
Infection
In Vitro Techniques

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

In vitro and in vivo activities of ciprofloxacin and levofloxacin against an SHV-5 extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain. / Szabó, D.; Máthé, András; Lengyel, József; Anderlik, Piroska; Rókusz, László; Rozgonyi, F.

In: Current Medicinal Chemistry, Vol. 9, No. 4, 2002, p. 437-442.

Research output: Contribution to journalArticle

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