In vitro and in vivo activities of amikacin, cefepime, amikacin plus cefepime, and imipenem against an SHV-5 extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain

D. Szabó, A. Máthé, Z. Filetóth, P. Anderlik, L. Rókusz, F. Rozgonyi

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Abstract

The in vitro and in vivo effectiveness of amikacin, cefepime, and imipenem was studied using a high inoculum of an extended-spectrum β-lactamase-producing Klebsiella pneumoniae strain. An in vitro susceptibility test at the standard inoculum predicted the in vivo outcome of amikacin or imipenem while it did not do so for cefepime due to the inoculum effect.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2 2001

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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