In vitro and ex vivo activity of thioridazine derivatives against Mycobacterium tuberculosis

Marta Martins, Zsuzsanna Schelz, Ana Martins, J. Molnár, G. Hajós, Z. Riedl, Miguel Viveiros, Ismail Yalcin, Esin Aki-Sener, Leonard Amaral

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Thioridazine (TZ) has previously been shown by us to have in vitro and ex vivo activity against antibiotic-susceptible and multidrug-resistant Mycobacterium tuberculosis (MDRTB). Because current therapy of MDRTB is highly problematic even when all five 'first line of defence' drugs are employed, there is a need for effective antituberculosis drugs. New derivatives of TZ were synthesised and their in vitro activity against a reference strain of M. tuberculosis was evaluated with the aid of the BACTEC 460 system. Derivatives that presented significant activity were evaluated by ex vivo studies and were shown to enhance the killing of intracellular M. tuberculosis.

Original languageEnglish
Pages (from-to)338-340
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume29
Issue number3
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Thioridazine
Mycobacterium tuberculosis
Multidrug-Resistant Tuberculosis
Pharmaceutical Preparations
Anti-Bacterial Agents
In Vitro Techniques

Keywords

  • Derivatives
  • Ex vivo activity
  • In vitro activity
  • Multidrug resistance
  • Mycobacterium tuberculosis
  • Thioridazine

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

In vitro and ex vivo activity of thioridazine derivatives against Mycobacterium tuberculosis. / Martins, Marta; Schelz, Zsuzsanna; Martins, Ana; Molnár, J.; Hajós, G.; Riedl, Z.; Viveiros, Miguel; Yalcin, Ismail; Aki-Sener, Esin; Amaral, Leonard.

In: International Journal of Antimicrobial Agents, Vol. 29, No. 3, 03.2007, p. 338-340.

Research output: Contribution to journalArticle

Martins, Marta ; Schelz, Zsuzsanna ; Martins, Ana ; Molnár, J. ; Hajós, G. ; Riedl, Z. ; Viveiros, Miguel ; Yalcin, Ismail ; Aki-Sener, Esin ; Amaral, Leonard. / In vitro and ex vivo activity of thioridazine derivatives against Mycobacterium tuberculosis. In: International Journal of Antimicrobial Agents. 2007 ; Vol. 29, No. 3. pp. 338-340.
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