In vitro activity of phenothiazines and their combinations with amphotericin B against Zygomycetes causing rhinocerebral zygomycosis

László Galgóczy, Tamás Papp, Laura Kovács, Lilla Ördögh, Csaba Vágvölgyi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The in vitro antifungal activities of two phenothiazine (PTZ) compounds, trifluoperazine (TFP) and chlorpromazine (CPZ) separately and in combination with amphotericin B (AMB) were tested against eight fungal isolates known to be possible agents of rhinocerebral zygomycosis. While both PTZs individually had antifungal effects against these filamentous fungi, only the antifungal activity of TFP increased in presence of AMB. TFP and AMB acted synergistically and caused full inhibition of all strains tested except for Absidia glauca. In contrast, CPZ was found to act antagonistically with AMB with all of studied isolates.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalMedical mycology
Volume47
Issue number3
DOIs
Publication statusPublished - Aug 17 2009

Keywords

  • Amphotericin B
  • Chlorpromazine
  • Rhinocerebral zygomycosis
  • Synergism
  • Trifluoperazine

ASJC Scopus subject areas

  • Infectious Diseases

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