In situ synthesis of molecularly imprinted nanoparticles in porous support membranes using high-viscosity polymerization solvents

Tibor Renkecz, K. László, V. Horváth

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

There is a growing need in membrane separations for novel membrane materials providing selective retention. Molecularly imprinted polymers (MIPs) are promising candidates for membrane functionalization. In this work, a novel approach is described to prepare composite membrane adsorbers incorporating molecularly imprinted microparticles or nanoparticles into commercially available macroporous filtration membranes. The polymerization is carried out in highly viscous polymerization solvents, and the particles are formed in situ in the pores of the support membrane. MIP particle composite membranes selective for terbutylazine were prepared and characterized by scanning electron microscopy and N2 porosimetry. By varying the polymerization solvent microparticles or nanoparticles with diameters ranging from several hundred nanometers to 1 μm could be embedded into the support. The permeability of the membranes was in the range of 1000 to 20 000 Lm-2hr -1bar-1. The imprinted composite membranes showed high MIP/NIP (nonimprinted polymer) selectivity for the template in organic media both in equilibrium-rebinding measurements and in filtration experiments. The solid phase extraction of a mixture of the template, its analogs, and a nonrelated compound demonstrated MIP/NIP selectivity and substance selectivity of the new molecularly imprinted membrane. The synthesis technique offers a potential for the cost-effective production of selective membrane adsorbers with high capacity and high throughput.

Original languageEnglish
Pages (from-to)320-329
Number of pages10
JournalJournal of Molecular Recognition
Volume25
Issue number6
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Viscosity
Polymerization
Nanoparticles
Membranes
Polymers
Solid Phase Extraction
Electron Scanning Microscopy
Permeability
Costs and Cost Analysis

Keywords

  • affinity adsorber
  • composite membrane
  • membrane solid phase extraction
  • molecularly imprinted polymer
  • nanoparticle
  • terbutylazine

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

@article{401dac027467464998b6b20b971f4057,
title = "In situ synthesis of molecularly imprinted nanoparticles in porous support membranes using high-viscosity polymerization solvents",
abstract = "There is a growing need in membrane separations for novel membrane materials providing selective retention. Molecularly imprinted polymers (MIPs) are promising candidates for membrane functionalization. In this work, a novel approach is described to prepare composite membrane adsorbers incorporating molecularly imprinted microparticles or nanoparticles into commercially available macroporous filtration membranes. The polymerization is carried out in highly viscous polymerization solvents, and the particles are formed in situ in the pores of the support membrane. MIP particle composite membranes selective for terbutylazine were prepared and characterized by scanning electron microscopy and N2 porosimetry. By varying the polymerization solvent microparticles or nanoparticles with diameters ranging from several hundred nanometers to 1 μm could be embedded into the support. The permeability of the membranes was in the range of 1000 to 20 000 Lm-2hr -1bar-1. The imprinted composite membranes showed high MIP/NIP (nonimprinted polymer) selectivity for the template in organic media both in equilibrium-rebinding measurements and in filtration experiments. The solid phase extraction of a mixture of the template, its analogs, and a nonrelated compound demonstrated MIP/NIP selectivity and substance selectivity of the new molecularly imprinted membrane. The synthesis technique offers a potential for the cost-effective production of selective membrane adsorbers with high capacity and high throughput.",
keywords = "affinity adsorber, composite membrane, membrane solid phase extraction, molecularly imprinted polymer, nanoparticle, terbutylazine",
author = "Tibor Renkecz and K. L{\'a}szl{\'o} and V. Horv{\'a}th",
year = "2012",
month = "6",
doi = "10.1002/jmr.2153",
language = "English",
volume = "25",
pages = "320--329",
journal = "Journal of Molecular Recognition",
issn = "0952-3499",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

TY - JOUR

T1 - In situ synthesis of molecularly imprinted nanoparticles in porous support membranes using high-viscosity polymerization solvents

AU - Renkecz, Tibor

AU - László, K.

AU - Horváth, V.

PY - 2012/6

Y1 - 2012/6

N2 - There is a growing need in membrane separations for novel membrane materials providing selective retention. Molecularly imprinted polymers (MIPs) are promising candidates for membrane functionalization. In this work, a novel approach is described to prepare composite membrane adsorbers incorporating molecularly imprinted microparticles or nanoparticles into commercially available macroporous filtration membranes. The polymerization is carried out in highly viscous polymerization solvents, and the particles are formed in situ in the pores of the support membrane. MIP particle composite membranes selective for terbutylazine were prepared and characterized by scanning electron microscopy and N2 porosimetry. By varying the polymerization solvent microparticles or nanoparticles with diameters ranging from several hundred nanometers to 1 μm could be embedded into the support. The permeability of the membranes was in the range of 1000 to 20 000 Lm-2hr -1bar-1. The imprinted composite membranes showed high MIP/NIP (nonimprinted polymer) selectivity for the template in organic media both in equilibrium-rebinding measurements and in filtration experiments. The solid phase extraction of a mixture of the template, its analogs, and a nonrelated compound demonstrated MIP/NIP selectivity and substance selectivity of the new molecularly imprinted membrane. The synthesis technique offers a potential for the cost-effective production of selective membrane adsorbers with high capacity and high throughput.

AB - There is a growing need in membrane separations for novel membrane materials providing selective retention. Molecularly imprinted polymers (MIPs) are promising candidates for membrane functionalization. In this work, a novel approach is described to prepare composite membrane adsorbers incorporating molecularly imprinted microparticles or nanoparticles into commercially available macroporous filtration membranes. The polymerization is carried out in highly viscous polymerization solvents, and the particles are formed in situ in the pores of the support membrane. MIP particle composite membranes selective for terbutylazine were prepared and characterized by scanning electron microscopy and N2 porosimetry. By varying the polymerization solvent microparticles or nanoparticles with diameters ranging from several hundred nanometers to 1 μm could be embedded into the support. The permeability of the membranes was in the range of 1000 to 20 000 Lm-2hr -1bar-1. The imprinted composite membranes showed high MIP/NIP (nonimprinted polymer) selectivity for the template in organic media both in equilibrium-rebinding measurements and in filtration experiments. The solid phase extraction of a mixture of the template, its analogs, and a nonrelated compound demonstrated MIP/NIP selectivity and substance selectivity of the new molecularly imprinted membrane. The synthesis technique offers a potential for the cost-effective production of selective membrane adsorbers with high capacity and high throughput.

KW - affinity adsorber

KW - composite membrane

KW - membrane solid phase extraction

KW - molecularly imprinted polymer

KW - nanoparticle

KW - terbutylazine

UR - http://www.scopus.com/inward/record.url?scp=84861604955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861604955&partnerID=8YFLogxK

U2 - 10.1002/jmr.2153

DO - 10.1002/jmr.2153

M3 - Article

VL - 25

SP - 320

EP - 329

JO - Journal of Molecular Recognition

JF - Journal of Molecular Recognition

SN - 0952-3499

IS - 6

ER -