In situ synthesis of molecularly imprinted nanoparticles in porous support membranes using high-viscosity polymerization solvents

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10 Citations (Scopus)

Abstract

There is a growing need in membrane separations for novel membrane materials providing selective retention. Molecularly imprinted polymers (MIPs) are promising candidates for membrane functionalization. In this work, a novel approach is described to prepare composite membrane adsorbers incorporating molecularly imprinted microparticles or nanoparticles into commercially available macroporous filtration membranes. The polymerization is carried out in highly viscous polymerization solvents, and the particles are formed in situ in the pores of the support membrane. MIP particle composite membranes selective for terbutylazine were prepared and characterized by scanning electron microscopy and N2 porosimetry. By varying the polymerization solvent microparticles or nanoparticles with diameters ranging from several hundred nanometers to 1 μm could be embedded into the support. The permeability of the membranes was in the range of 1000 to 20 000 Lm-2hr -1bar-1. The imprinted composite membranes showed high MIP/NIP (nonimprinted polymer) selectivity for the template in organic media both in equilibrium-rebinding measurements and in filtration experiments. The solid phase extraction of a mixture of the template, its analogs, and a nonrelated compound demonstrated MIP/NIP selectivity and substance selectivity of the new molecularly imprinted membrane. The synthesis technique offers a potential for the cost-effective production of selective membrane adsorbers with high capacity and high throughput.

Original languageEnglish
Pages (from-to)320-329
Number of pages10
JournalJournal of Molecular Recognition
Volume25
Issue number6
DOIs
Publication statusPublished - Jun 1 2012

Keywords

  • affinity adsorber
  • composite membrane
  • membrane solid phase extraction
  • molecularly imprinted polymer
  • nanoparticle
  • terbutylazine

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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