In situ oxidation-induced gelation of poly(aspartic acid) thiomers

Benjámin Gyarmati, Eniko Krisch, A. Szilágyi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In situ gelling poly(aspartic acid) thiomers are investigated to demonstrate their potential application in the development of injectable formulations. The chemical stability of the thiomer solutions is measured against air to determine the maximum storage time of the solution before injection. Hydrogels exhibit considerably large storage moduli after the chemical oxidation of the low-viscosity thiomer solution. The gelation time can be controlled within 2-6 min, which is advantageous for injection because the thiomer solution and the oxidising agent can be mixed safely in a two-chamber system before injection into the desired site of the body.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalReactive and Functional Polymers
Volume84
DOIs
Publication statusPublished - 2014

Fingerprint

aspartic acid
Gelation
Aspartic Acid
oxidation
Oxidation
Injections
Acids
Hydrogels
Chemical stability
Oxidants
Viscosity
viscosity
Elastic moduli
Air
in situ
air
chemical

Keywords

  • Disulphide formation
  • Injectable polymers
  • Poly(aspartic acid)
  • Rheology
  • Thiolated polymers

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Chemistry(all)
  • Chemical Engineering(all)
  • Environmental Chemistry
  • Biochemistry

Cite this

In situ oxidation-induced gelation of poly(aspartic acid) thiomers. / Gyarmati, Benjámin; Krisch, Eniko; Szilágyi, A.

In: Reactive and Functional Polymers, Vol. 84, 2014, p. 29-36.

Research output: Contribution to journalArticle

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