In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis

Ildikó Rostás, László Pótó, Péter Mátrai, Péter Hegyi, Judit Tenk, András Garami, Anita Illés, Margit Solymár, Erika Pétervári, Ákos Szűcs, Andrea Párniczky, Dániel Pécsi, Zoltán Rumbus, Csaba Zsiborás, Nóra Füredi, Márta Balaskó

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7 Citations (Scopus)

Abstract

Background: Leptin is one of the major adipokines in obesity that indicates the severity of fat accumulation. It is also an important etiological factor of consequent cardiometabolic and autoimmune disorders. Aging has been demonstrated to aggravate obesity and to induce leptin resistance and hyperleptinemia. Hyperleptinemia, on the other hand, may promote the development of age-related abnormalities. While major weight loss has been demonstrated to ameliorate hyperleptinemia, obese people show a poor tendency to achieve lasting success in this field. The question arises whether training intervention per se is able to reduce the level of this adipokine. Objectives: We aimed to review the literature on the effects of training intervention on peripheral leptin level in obesity during aging, in order to evaluate the independent efficacy of this method. In the studies that were included in our analysis, changes of adiponectin levels (when present) were also evaluated. Data sources: 3481 records were identified through searching of PubMed, Embase and Cochrane Library Database. Altogether 19 articles were suitable for analyses. Study eligibility criteria: Empirical research papers were eligible provided that they reported data of middle-aged or older (above 45 years of age) overweight or obese (body mass index above 25) individuals and included physical training intervention or at least fitness status of groups together with corresponding blood leptin values. Statistical methods: We used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods. I-squared indicator and Q test were performed to assess heterogeneity. To assess publication bias Egger’s test was applied. In case of significant publication bias, the Duval and Tweedie’s trim and fill algorithm was used. Results: Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. Resistance training appears to be more efficient in reducing blood leptin level than aerobic training alone. Conclusions: Physical training, especially resistance training successfully reduces hyperleptinemia even without diet or major weight loss.

Original languageEnglish
Article numbere0182801
JournalPloS one
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Rostás, I., Pótó, L., Mátrai, P., Hegyi, P., Tenk, J., Garami, A., Illés, A., Solymár, M., Pétervári, E., Szűcs, Á., Párniczky, A., Pécsi, D., Rumbus, Z., Zsiborás, C., Füredi, N., & Balaskó, M. (2017). In middle-aged and old obese patients, training intervention reduces leptin level: A meta-analysis. PloS one, 12(8), [e0182801]. https://doi.org/10.1371/journal.pone.0182801