In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia

A. Gézsi, O. Lautner-Csorba, D. J. Erdélyi, G. Hullám, P. Antal, F. Semsei, N. Kutszegi, M. Hegyi, K. Csordás, G. Kovács, C. Szalai

Research output: Contribution to journalArticle

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Abstract

CYP3A4 has an important role in the metabolisms of many drugs used in acute lymphoblastic leukemia (ALL) therapy; still, there are practically no publications about the role of CYP3A4 polymorphisms in ALL pharmacogenomics. We genotyped eight common single-nucleotide polymorphisms (SNPs) in the CYP3A4 and CYP3A5 genes in 511 children with ALL and investigated whether they influenced the survival of the patients. We involved additional 127 SNPs in 34 candidate genes and searched for interactions with respect to the survival rates. Significant association between the survival rates and the common rs2246709 SNP in the CYP3A4 gene was observed. The gender of the patients and the rs1076991 in the MTHFD1 gene strongly influenced this effect. We calculated new risk assessments involving the gender-rs2246709 interaction and showed that they significantly outperformed the earlier risk-group assessments at every time point. If this finding is confirmed in other populations, it can have a considerable prognostic significance.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalPharmacogenomics Journal
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 26 2015

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Cytochrome P-450 CYP3A
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival Rate
Drug Therapy
Single Nucleotide Polymorphism
Genes
Pharmacogenetics
Publications
Survival
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics

Cite this

In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia. / Gézsi, A.; Lautner-Csorba, O.; Erdélyi, D. J.; Hullám, G.; Antal, P.; Semsei, F.; Kutszegi, N.; Hegyi, M.; Csordás, K.; Kovács, G.; Szalai, C.

In: Pharmacogenomics Journal, Vol. 15, No. 3, 26.06.2015, p. 241-247.

Research output: Contribution to journalArticle

Gézsi, A, Lautner-Csorba, O, Erdélyi, DJ, Hullám, G, Antal, P, Semsei, F, Kutszegi, N, Hegyi, M, Csordás, K, Kovács, G & Szalai, C 2015, 'In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia', Pharmacogenomics Journal, vol. 15, no. 3, pp. 241-247. https://doi.org/10.1038/tpj.2014.60
Gézsi, A. ; Lautner-Csorba, O. ; Erdélyi, D. J. ; Hullám, G. ; Antal, P. ; Semsei, F. ; Kutszegi, N. ; Hegyi, M. ; Csordás, K. ; Kovács, G. ; Szalai, C. / In interaction with gender a common CYP3A4 polymorphism may influence the survival rate of chemotherapy for childhood acute lymphoblastic leukemia. In: Pharmacogenomics Journal. 2015 ; Vol. 15, No. 3. pp. 241-247.
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AU - Semsei, F.

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