Improving control of hypertension by an integrated approach - Results of the 'Manage it well!' programme

Laszlo A. Szirmai, Csaba Arnold, Csaba Farsang

Research output: Contribution to journalArticle

13 Citations (Scopus)


Background: Patient non-compliance is a significant contributor to poor blood pressure control. Although measures to improve compliance are known, they are not in routine use. Objective: To apply measures based on current recommendations in an integrated approach in the 'Manage it well!' (MIW) programme, and to determine the improvement in blood pressure control. Design and setting: During the prospective open cohort study, 348 primary and 156 secondary care centres enrolled 6941 hypertensive patients and followed them for 6 months. Interventions: An integrated intervention package also applicable to everyday practice was introduced to improve treatment adherence, including education programmes for patients and physicians, tight follow-up with frequent office visits and regular home blood pressure measurements. Treatment was based on either trandolapril or verapamil SR with dose titration, with added-on therapy if necessary. Main outcome measure: Rates of control of blood pressure to < 140/90 mmHg. Results: Data were evaluated from 5468 patients, 72% known to have hypertension and 26% newly diagnosed [2% not available (n.a.)]. At baseline only 2.9% of treated patients had their hypertension well controlled (< 140/ 90 mmHg), but during the programme this increased to 40.9% (P < 0.001). The absolute reduction in office blood pressure was also significant (from 168 ± 19/ 97 ± 11 mmHg to 139 ± 13/83 ± 7 mmHg; P< 0.001). No differences in blood pressure control were found between trandolapril and verapamil SR regimens. Office blood pressure was greater than home blood pressure at baseline (168 ± 19/97 ± 11 mmHg compared with 151 ± 17/89 ± 10 mmHg; P < 0.001), but this difference disappeared at 6 months (139 ± 13/83 ± 7 mmHg compared with 140 ± 13/84 ± 7 mmHg, respectively). Conclusions: The integrated, patient-focused approach used in the MIW programme significantly increases the success of treatment in a 'real-world' setting.

Original languageEnglish
Pages (from-to)203-211
Number of pages9
JournalJournal of hypertension
Issue number1
Publication statusPublished - Jan 2005


  • Adherence
  • Compliance
  • Control rate
  • Diastolic blood pressure
  • Home blood pressure measurement
  • Hypertension
  • Responder
  • Systolic blood pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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