Improvement of the Physicochemical Properties of Clotrimazole by Cyclodextrin Complexation

Filiz Taneri, Tamer Guneri, Zoltán Aigner, Istráu Erös, Michael Kata

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Complex formation between CDs and a very poorly water-soluble antifungal agent, clotrimazole (CLT), was studied. Products containing γ-CD were prepared in two molecular ratios by four methods. The rates of dissolution of the 1:1 drug/CD combinations revealed better dissolution properties than those of the 1:2 products. Drug/CD interactions in both aqueous solution and the solid state were studied by phase solubility and thermal analysis. The effects of different auxiliary materials (polymers, hydroxy acids and surfactants) on the aqueous solubility of CLT were investigated. The aqueous solubility of CLT was increased significantly by the addition of the auxiliary materials. Particle size distribution, partition coefficient, surface tension, heat of dissolution and wettability studies were also carried out.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Inclusion Phenomena
Volume46
Issue number1-2
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Clotrimazole
  • Cyclodextrin inclusion complexes
  • Heat of dissolution
  • Particle size distribution
  • Partition coefficient
  • Solubility properties
  • Surface tension
  • Wettability

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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