Improvement of small intestinal microcirculation by postconditioning after lower limb ischemia

Zsolt Turóczi, András Fülöp, Zoltán Czigány, Gabriella Varga, Oliver Rosero, Tünde Tökés, József Kaszaki, Gábor Lotz, László Harsányi, Attila Szijártó

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3 Citations (Scopus)

Abstract

Major lower limb vascular surgeries may result in severe, remote injury of the gastrointestinal system, which has high mortality rates. Postconditioning is a technique with potential capability of reducing remote gastrointestinal complications. Our aim was to assess the remote macro- and micro-hemodynamic changes of the small intestine following an infrarenal aortic occlusion and to evaluate the effects of postconditioning on these alterations. Methods: Rats underwent 3. h of infrarenal aortic occlusion followed by 4. h of reperfusion. In one group, postconditioning was applied. Blood pressure, superior mesenteric artery flow and mucosal microcirculation of the duodenum, jejunum and ileum were assessed. Samples were taken from each intestinal segment for histological examinations. Results: Superior mesenteric artery flow, as well as microcirculation of the duodenum, jejunum and ileum showed significant impairment in the IR group, while histological damage was significantly worsened. Postconditioning was able to limit flow reduction in all three small bowel segments and in the superior mesenteric artery, and was able to significantly reduce histological damage. Strong negative correlation was found between microcirculatory values and histological damage. Conclusions: Microcirculatory impairment might be responsible for remote intestinal injury following infrarenal aortic occlusion. Postconditioning was able to reduce this remote intestinal damage.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalMicrovascular Research
Volume98
DOIs
Publication statusPublished - Mar 1 2015

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Keywords

  • Lower limb ischemia
  • Microcirculation
  • Postconditioning
  • Small intestine
  • Superior mesenteric artery flow

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Turóczi, Z., Fülöp, A., Czigány, Z., Varga, G., Rosero, O., Tökés, T., Kaszaki, J., Lotz, G., Harsányi, L., & Szijártó, A. (2015). Improvement of small intestinal microcirculation by postconditioning after lower limb ischemia. Microvascular Research, 98, 119-125. https://doi.org/10.1016/j.mvr.2015.02.001