Increasing muscle mass and force is the aim of some body builders and sportsmen, and is a therapeutic target in hormonal deficiencies, as well as in many clinical situations, when muscle devastation is a life-limitating factor. Human growth hormone, insulin-like growth factor, anabolic-andogen steroids and regulating proteins influencing muscle development and differentiation are used also for refrainment of aging processes. Some of the practices are haloed by several myths, mainly because dopping-cases in certain competitive sports. Physiology, and therapeutical experiences with these substances are reviewed with special reference to the physical exercise and to some frail conditions.
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