Improvement of mechanical properties of pellet containing tablets by thermal treatment

Zsombor Csobán, Barnabás Kállai-Szabó, Nikolett Kállai-Szabó, István Sebe, P. Gordon, I. Antal

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Batches of partially spray-dried lactose tablets with three different initial tensile strength (∼20 N, ∼35 N, ∼50 N) were made. Changes along a 24 h long thermal treatment at 100 °C in tensile strength, friability, individual mass, water content, disintegration time, average free volume and wetting properties were evaluated. Caffeine containing gastroresistant pellets were gained by drug layering and filmcoating of inert microcrystalline cellulose pellet cores in fluid bed equipment. Shape, size, mechanical properties, drug content and dissolution profile of the coated pellets were determined. Batches of pellet containing tablets with three different pellet-filler ratios were compressed where partially spray-dried lactose was used as a filler-binder material.Characteristics of pellet containing tablets were evaluated before and after a 24 h long thermal treatment at 100 °C. Results shown that the poor initial mechanical properties (friability, tensile strength) were improved by thermal exposure while there were no remarkable alterations in drug release profiles.

Original languageEnglish
Pages (from-to)489-496
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume496
Issue number2
DOIs
Publication statusPublished - Dec 30 2015

Fingerprint

Tensile Strength
Tablets
Hot Temperature
Lactose
Caffeine
Equipment and Supplies
Water
Pharmaceutical Preparations
Drug Liberation

Keywords

  • Dissolution profile
  • Multiple-unit pellet system (MUPS)
  • Reduced friability
  • Spray-dried lactose
  • Tablet hardness
  • Thermal treatment

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Improvement of mechanical properties of pellet containing tablets by thermal treatment. / Csobán, Zsombor; Kállai-Szabó, Barnabás; Kállai-Szabó, Nikolett; Sebe, István; Gordon, P.; Antal, I.

In: International Journal of Pharmaceutics, Vol. 496, No. 2, 30.12.2015, p. 489-496.

Research output: Contribution to journalArticle

Csobán, Zsombor ; Kállai-Szabó, Barnabás ; Kállai-Szabó, Nikolett ; Sebe, István ; Gordon, P. ; Antal, I. / Improvement of mechanical properties of pellet containing tablets by thermal treatment. In: International Journal of Pharmaceutics. 2015 ; Vol. 496, No. 2. pp. 489-496.
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