Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy

A. Blázovics, Agnes Szilvás, György Székely, Eniko Tordai, Edit Székely, Gábor Czabai, Zsolt Pallai, Eva Sárdi

Research output: Contribution to journalArticle

Abstract

Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer and it has pro- and antioxidant forms depending on concentrations. The aim was to determine the amount of HCHO and protoporphyrin concentrations of erythrocytes in colorectal cancer after colectomy and to estimate redox homeostasis. Total 32 adult patients after 5-10 years of colectomy and 9 healthy volunteers were drawn into this study. Tumor markers, redox parameters, HbA1c, HCHO and protoporphyrin concentrations were measured. Erytrocyte HCHO was significantly lower in colectomysed patients, than in controls. Protoporphyrin concentration was low in patients, but in metastasis its concentration was significant. HbA1c correlated significantly with free radicals and decreased the antioxidant status of erythrocytes. HCHO and protoporphyrin concentrations of erythrocytes and the total scavenger capacity are very important indexes in cancer.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalThe open medicinal chemistry journal
Volume2
DOIs
Publication statusPublished - Feb 27 2008

Fingerprint

Colectomy
Colorectal Neoplasms
Erythrocytes
Oxidation-Reduction
Homeostasis
Antioxidants
Tumor Biomarkers
protoporphyrin IX
Formaldehyde
Free Radicals
Neoplasms
Healthy Volunteers
Neoplasm Metastasis

Keywords

  • Colorectal cancer
  • HCHO
  • protoporphyrin
  • redox homeostasis.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy. / Blázovics, A.; Szilvás, Agnes; Székely, György; Tordai, Eniko; Székely, Edit; Czabai, Gábor; Pallai, Zsolt; Sárdi, Eva.

In: The open medicinal chemistry journal, Vol. 2, 27.02.2008, p. 6-10.

Research output: Contribution to journalArticle

Blázovics, A. ; Szilvás, Agnes ; Székely, György ; Tordai, Eniko ; Székely, Edit ; Czabai, Gábor ; Pallai, Zsolt ; Sárdi, Eva. / Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy. In: The open medicinal chemistry journal. 2008 ; Vol. 2. pp. 6-10.
@article{f6bad495bf2d441b91669ef78bf20ea3,
title = "Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy",
abstract = "Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer and it has pro- and antioxidant forms depending on concentrations. The aim was to determine the amount of HCHO and protoporphyrin concentrations of erythrocytes in colorectal cancer after colectomy and to estimate redox homeostasis. Total 32 adult patients after 5-10 years of colectomy and 9 healthy volunteers were drawn into this study. Tumor markers, redox parameters, HbA1c, HCHO and protoporphyrin concentrations were measured. Erytrocyte HCHO was significantly lower in colectomysed patients, than in controls. Protoporphyrin concentration was low in patients, but in metastasis its concentration was significant. HbA1c correlated significantly with free radicals and decreased the antioxidant status of erythrocytes. HCHO and protoporphyrin concentrations of erythrocytes and the total scavenger capacity are very important indexes in cancer.",
keywords = "Colorectal cancer, HCHO, protoporphyrin, redox homeostasis.",
author = "A. Bl{\'a}zovics and Agnes Szilv{\'a}s and Gy{\"o}rgy Sz{\'e}kely and Eniko Tordai and Edit Sz{\'e}kely and G{\'a}bor Czabai and Zsolt Pallai and Eva S{\'a}rdi",
year = "2008",
month = "2",
day = "27",
doi = "10.2174/1874104500802010006",
language = "English",
volume = "2",
pages = "6--10",
journal = "Open Medicinal Chemistry Journal",
issn = "1874-1045",
publisher = "Bentham Science Publishers B.V.",

}

TY - JOUR

T1 - Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy

AU - Blázovics, A.

AU - Szilvás, Agnes

AU - Székely, György

AU - Tordai, Eniko

AU - Székely, Edit

AU - Czabai, Gábor

AU - Pallai, Zsolt

AU - Sárdi, Eva

PY - 2008/2/27

Y1 - 2008/2/27

N2 - Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer and it has pro- and antioxidant forms depending on concentrations. The aim was to determine the amount of HCHO and protoporphyrin concentrations of erythrocytes in colorectal cancer after colectomy and to estimate redox homeostasis. Total 32 adult patients after 5-10 years of colectomy and 9 healthy volunteers were drawn into this study. Tumor markers, redox parameters, HbA1c, HCHO and protoporphyrin concentrations were measured. Erytrocyte HCHO was significantly lower in colectomysed patients, than in controls. Protoporphyrin concentration was low in patients, but in metastasis its concentration was significant. HbA1c correlated significantly with free radicals and decreased the antioxidant status of erythrocytes. HCHO and protoporphyrin concentrations of erythrocytes and the total scavenger capacity are very important indexes in cancer.

AB - Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer and it has pro- and antioxidant forms depending on concentrations. The aim was to determine the amount of HCHO and protoporphyrin concentrations of erythrocytes in colorectal cancer after colectomy and to estimate redox homeostasis. Total 32 adult patients after 5-10 years of colectomy and 9 healthy volunteers were drawn into this study. Tumor markers, redox parameters, HbA1c, HCHO and protoporphyrin concentrations were measured. Erytrocyte HCHO was significantly lower in colectomysed patients, than in controls. Protoporphyrin concentration was low in patients, but in metastasis its concentration was significant. HbA1c correlated significantly with free radicals and decreased the antioxidant status of erythrocytes. HCHO and protoporphyrin concentrations of erythrocytes and the total scavenger capacity are very important indexes in cancer.

KW - Colorectal cancer

KW - HCHO

KW - protoporphyrin

KW - redox homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=77951796304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951796304&partnerID=8YFLogxK

U2 - 10.2174/1874104500802010006

DO - 10.2174/1874104500802010006

M3 - Article

VL - 2

SP - 6

EP - 10

JO - Open Medicinal Chemistry Journal

JF - Open Medicinal Chemistry Journal

SN - 1874-1045

ER -