Importance of plasma cells in the infiltrate of renal allografts. An immunohistochemical study

T. Nadasdy, T. Krenács, K. N. Kalmar, E. Csajbok, K. Boda, J. Ormos

Research output: Contribution to journalArticle

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Abstract

The cellular infiltration in 42 needle and wedge biopsies of transplanted kidneys was investigated immunohistochemically. The percentages of helper/inducer (CD 4+) cells, suppressor/cytotoxic cells (CD 8+), B lymphocytes, macrophages, plasma cells (Pc) and granulocytes were determined. The proportions of the various inflammatory cell populations were established in acute interstitial rejection (AIR), acute vascular rejection (AVR), chronic rejection (CR) and cyclosporin A nephrotoxicity (CsAN). The most prominent differences were detected as regards the Pc, whose number was much higher in CR than in AIR, AVR or CsAN. The striking difference between CR and CsAN in the number of Pc may be of differential diagnostic importance: the presence of many Pc in the biopsies can be regarded as a sign of CR. Over 80% of the Pc in CR contained IgG, whereas in chronic interstitial nephritis (CIN) the IgA-positive Fc predominated. In AIR, AVR and CsAN, too, the majority of the Fc contained IgG, but the numbers of IgM and IgA-positive cells were also relatively high. The great number of IgG-positive Pc indicates an important role of a secondary type humoral immune response in CR.

Original languageEnglish
Pages (from-to)178-183
Number of pages6
JournalPathology Research and Practice
Volume187
Issue number2-3
Publication statusPublished - 1991

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Plasma Cells
Allografts
Kidney
Cyclosporine
Blood Vessels
Immunoglobulin G
Immunoglobulin A
Interstitial Nephritis
Needle Biopsy
Humoral Immunity
Granulocytes
Immunoglobulin M
B-Lymphocytes
Cell Count
Macrophages
Biopsy
Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Importance of plasma cells in the infiltrate of renal allografts. An immunohistochemical study. / Nadasdy, T.; Krenács, T.; Kalmar, K. N.; Csajbok, E.; Boda, K.; Ormos, J.

In: Pathology Research and Practice, Vol. 187, No. 2-3, 1991, p. 178-183.

Research output: Contribution to journalArticle

Nadasdy, T. ; Krenács, T. ; Kalmar, K. N. ; Csajbok, E. ; Boda, K. ; Ormos, J. / Importance of plasma cells in the infiltrate of renal allografts. An immunohistochemical study. In: Pathology Research and Practice. 1991 ; Vol. 187, No. 2-3. pp. 178-183.
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