Importance of myocardial blood flow changes in the protective action of diltiazem in a new model of myocardial ischaemia

L. Szekeres, Éva Udvary, Ágnes Végh

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Abstract

The effect of diltiazem was studied in a new model of myocardial ischaemia in which in addition to a critical constriction of the left circumflex branch (LCX), the left anterior descending coronary artery (LAD) was suddenly occluded. This model is probably more relevant to the clinical situation in which multivessel coronary artery disease is common. In this model diltiazem exerted a beneficial effect, manifested by an increase in myocardial blood flow (MBF) within the stenosed area of the LCX; by a marked reduction of the enhanced preload (LVEDP); by a diminution of the inhomogeneity of electrical activation and by a decrease in ST‐segment elevation. Diltiazem also caused a significant reduction both in the number of extrasystoles and in the incidence of ventricular fibrillation. Increased MBF within the stenosed area was associated with enhanced blood flow to the ischaemic myocardium, i.e. diltiazem directed flow to the ischaemic zone by improvement of the collateral circulation. The beneficial electrophysiological changes caused by diltiazem are probably at least partly due to the drug‐induced improvement of myocardial blood supply to the ischaemic area. 1985 British Pharmacological Society

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalBritish journal of pharmacology
Volume86
Issue number2
DOIs
Publication statusPublished - Oct 1985

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ASJC Scopus subject areas

  • Pharmacology

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