Importance of intestinal microenvironment in development of arthritis. A systematic review

Anna Bazsó, Péter Szodoray, Gábor Sütő, Yehuda Shoenfeld, Gyula Poór, Emese Kiss

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A strong connection between spondylarthropathies and inflammatory bowel diseases (IBD) is well established. About 10–15 % of IBD are associated with different forms of spondylarthritis. Arthritis can be manifested as axial, peripheral form or both. The primary functions of the gastrointestinal tract are digestion and absorption of nutrients, electrocytes and maintenance of water homoeostasis. The anatomic and functional lesions could lead to the development of IBD based on molecular mimicry and bystander effects. The mechanism of the macromolecules is uptaken may affect intestinal and extraintestinal manifestation in genetically susceptible individuals by gut-associated lymphoid tissue, the interplay between innate and adaptive immunity and the neuroendocrine network.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalImmunologic Research
Volume61
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • Colonisation
  • Gut
  • Intestinal microenvironment
  • Spondylarthropathy

ASJC Scopus subject areas

  • Immunology

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