Határfelületi tulajdonságok jelentosége a gyógyszertechnológiában

Translated title of the contribution: Importance of interfacial characteristics in the pharmaceutical technology

Judit Dredán, Gabriella Csóka, Sylvia Marton, István Antal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Since drug release from the dosage forms has priority to absorption from the gastrointestinal system, physico-chemical characterisation of pharmaceutical systems is essential during the development of an optimal formulation with high efficacy and quality. Interfacial parameters of several pharmaceutical excipients were studied regarding their possible modifying effect on drug release from the dosage form. These inactive ingredients may influence the interfacial phenomena of the drug carrier system, which behaviour determines both the efficacy and the quality of the pharmaceutical preparation. In this work authors deal mainly with the two introducing steps of the LADME model influenced by interfacial parameters on them, namely with the liberation of drugfrom the dosage form and with the characteristics influencing the absorption through biological membranes, respectively. The objective of the present work was to study modifying effects of excipients on drug liberation in connection with their physical and chemical characteristics such as interfacial tension of solid and liquid phases, wetting contact angle of solid phase and - a calculated quantity, - adhesion tension of the solid particles.

Translated title of the contributionImportance of interfacial characteristics in the pharmaceutical technology
Original languageHungarian
Pages (from-to)147-151
Number of pages5
JournalActa pharmaceutica Hungarica
Volume73
Issue number3
Publication statusPublished - Oct 30 2003

ASJC Scopus subject areas

  • Pharmaceutical Science

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