Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology

Gabor Valcz, F. Sípos, Z. Tulassay, B. Molnár, Yukako Yagi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Carcinoma-associated fibroblast (CAF) as prominent cell type of the tumour microenvironment has complex interaction with both the cancer cells and other nonneoplastic surrounding cells. The CAF-derived regulators and extracellular matrix proteins can support cancer progression by providing a protective microenvironment for the cancer cells via reduction of chemotherapy sensitivity. On the other hand, these proteins may act as powerful prognostic markers as well as potential targets of anticancer therapy. In this review, we summarise the clinical importance of the major CAF-derived signals influencing tumour behaviour and determining the outcome of chemotherapy.

Original languageEnglish
Pages (from-to)1026-1031
Number of pages6
JournalJournal of Clinical Pathology
Volume67
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

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Medical Oncology
Cellular Microenvironment
Tumor Microenvironment
Fibroblasts
Carcinoma
Drug Therapy
Neoplasms
Proteins
Extracellular Matrix Proteins
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology. / Valcz, Gabor; Sípos, F.; Tulassay, Z.; Molnár, B.; Yagi, Yukako.

In: Journal of Clinical Pathology, Vol. 67, No. 12, 01.12.2014, p. 1026-1031.

Research output: Contribution to journalArticle

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